当前位置: X-MOL 学术Adv. Healthcare Mater. › 论文详情
Acid‐Triggered Charge‐Convertible Graphene‐Based All‐in‐One Nanocomplex for Enhanced Genetic Phototherapy of Triple‐Negative Breast Cancer
Advanced Healthcare Materials ( IF 6.270 ) Pub Date : 2019-12-04 , DOI: 10.1002/adhm.201901187
Chunhui Wu; Yuan Tian; Yingxue Zhang; Jiming Xu; Yikun Wang; Xiaotian Guan; Tingting Li; Hong Yang; Shun Li; Xiang Qin; Yiyao Liu

Highly efficient and stimulus‐responsive nanomedicines for cancer treatment are currently receiving tremendous attention. In this study, an acid‐triggered charge‐reversible graphene‐based all‐in‐one nanocomplex is appropriately designed by surface modification with multilayer polymers and simultaneous co‐transportation of photosensitizer indocyanine green (ICG) and oligonucleotide inhibitor of miR‐21 (miR‐21i) to achieve highly efficient genetic phototherapy in a controlled manner. The nanocomplex (denoted as GPCP/miR‐21i/ICG) effectively protects miR‐21i from degradation and exhibits excellent photothermal/photochemical reactive oxygen species (ROS) generation as well as fluorescence imaging ability. The cargoes ICG and miR‐21i can significantly be released at acidic pH compared with normal physiological medium and escaped from endosomes/lysosomes due to the acid‐triggered charge reversal effect. Typically, the released miR‐21i downregulate the endogenous miR‐21 and result in the upregulation of the target proteins PTEN and Bax, thus increasing the phototherapeutic efficiency of ICG. High in vivo anticancer efficiency against the MDA‐MB‐231 triple‐negative breast cancer (TNBC) model is obtained due to the combination of genetic regulation of miR‐21i and the photokilling effect of ICG. This work highlights the great potential of this smart nanocomplex as an attractive modality of gene‐photo combined treatment of cancer, especially for intractable TNBC.
更新日期:2020-01-08

 

全部期刊列表>>
Springer Nature 2019高下载量文章和章节
化学/材料学中国作者研究精选
《科学报告》最新环境科学研究
ACS材料视界
自然科研论文编辑服务
中南大学国家杰青杨华明
南开大学陈弓课题组招聘启事
中南大学
材料化学和生物传感方向博士后招聘
课题组网站
X-MOL
北京大学分子工程苏南研究院
华东师范大学分子机器及功能材料
中山大学化学工程与技术学院
试剂库存
天合科研
down
wechat
bug