Pentamethine sulfobenzoindocyanine dyes with low net charge states and high photostability.,Photochemical & Photobiological Sciences

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Pentamethine sulfobenzoindocyanine dyes with low net charge states and high photostability.
Photochemical & Photobiological Sciences ( IF 2.7 ) Pub Date : 2020-01-22 , DOI: 10.1039/c9pp00445a
Damien E Dobson ₁ , Emily R Mahoney ₁ , Toan P Mach ₁ , Ryan J LeTourneau ₁ , Hans F Schmitthenner ₁

Affiliation

A series of Cy5.5 dye analogs and targeted probes with net charges varied from -3 to 0 were synthesized by an optimized method, followed by comparing their spectral and photostability properties in saturated solutions of air, oxygen, and argon. The Cy5.5 analogs with reduced charge were relatively stable when irridated at their excitation maxima, with a trend of higher stability with lower net charge states. The photostability of dyes was markedly lower in pure oxygen and higher in inert argon relative to ambient atmospheric conditions. The stability of c(RGDyK) conjugates as models of targeted molecular imaging agents mirrored these results and demonstrated the practical utility of the new family of Cy5.5 fluorophores.

中文翻译：

五次甲基磺基苯并吲哚菁染料具有低净电荷态和高光稳定性。

采用优化方法合成了一系列净电荷为-3到0的Cy5.5染料类似物和靶向探针，并比较了它们在空气、氧气和氩气饱和溶液中的光谱和光稳定性。当在其激发最大值下进行照射时，电荷减少的 Cy5.5 类似物相对稳定，并且具有随着净电荷态较低而稳定性较高的趋势。相对于环境大气条件，染料的光稳定性在纯氧中明显较低，在惰性氩气中较高。c(RGDyK) 缀合物作为靶向分子成像剂模型的稳定性反映了这些结果，并证明了新的 Cy5.5 荧光团家族的实用性。

更新日期：2020-02-13

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