Biodegradation of Bi-Labeled Polymer-Coated Rare-Earth Nanoparticles in Adherent Cell Cultures,Chemistry of Materials

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Biodegradation of Bi-Labeled Polymer-Coated Rare-Earth Nanoparticles in Adherent Cell Cultures
Chemistry of Materials ( IF 7.2 ) Pub Date : 2019-12-30 , DOI: 10.1021/acs.chemmater.9b03673
Ziyao Liu ₁ , Alberto Escudero _{2,

3} , Carolina Carrillo-Carrion _{4,

5} , Indranath Chakraborty ₁ , Dingcheng Zhu ₁ , Marta Gallego ₄ , Wolfgang J. Parak _{1,

4} , Neus Feliu ₁

Affiliation

The fate of polymer-coated Eu- and Bi-doped GdVO₄ nanoparticles (NPs) of cubic shape upon cellular internalization was investigated. After having been endocytosed by cells, the cubic Eu- and Bi-doped GdVO₄ NP cores were partly dissolved and reshaped to rounded structures, which in control experiments could be ascribed to the acidic conditions present in endosomes/lysosomes. With progress of time, there was a significant reduction in the amount of internalized NPs per cell due to proliferation. This was of higher extent than NP exocytosis. Data of the study are compatible with the scenario that endosomal/lysosomal enzymes may partly digest the polymer shell around the NP cores, with enhanced exocytosis of the polymer fragments as compared to the NP cores.

中文翻译：

双标签聚合物包被的稀土纳米颗粒在贴壁细胞培养物中的生物降解

研究了聚合物包被的Eu和Bi掺杂的立方形状的GdVO ₄纳米颗粒（NPs）在细胞内化后的命运。在被细胞内吞后，立方的Eu和Bi掺杂的GdVO ₄ NP核被部分溶解并重塑为圆形结构，这在对照实验中可归因于内体/溶酶体中的酸性条件。随着时间的推移，由于增殖，每个细胞内化NP的数量显着减少。这比NP胞吐作用更高。这项研究的数据与内体/溶酶体酶可能部分消化NP核周围的聚合物壳的情况相符，与NP核相比，聚合物片段的胞吐作用增强。

更新日期：2019-12-31

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