OBJECTIVE This study was designed to retrospectively analyze the value of the hematological parameter platelet to lymphocyte ratio (PLR) and hemoglobin to platelet ratio (HPR) in patients with colon cancer. METHODS The hematological parameters and clinical data of 354 cases patients with colon cancer, 108 cases patients with benign colon tumors and 123 healthy controls were collected from our hospital electronic medical records. RESULTS Compared with the colon benign tumor group and the healthy control group, the colon cancer group had an increased PLR value and a decreased HPR value. The correlation between the clinicopathological features and the laboratory parameters of colon cancer patients was analyzed, and the results showed that both PLR and HPR were associated with tumor invasion and tumor size. Compared with PLR (AUC = 0.725, 95%CI: 0.682-0.765), HPR (AUC = 0.752, 95%CI: 0.710-0.790) or carcinoembryonic antigen (CEA) (AUC = 0.710, 95%CI: 0.666-0.751) used alone, the combination with PLR and CEA (AUC = 0.790, 95%CI: 0.750-0.826) or with HPR and CEA (AUC = 0.814, 95%CI: 0.775-0.848) can improve specificity and produce greater AUC in differentiating colon cancer from benign colon cancer. CONCLUSION Combined application of PLR, HPR, and CEA may improve the diagnostic efficacy of distinguishing between colon cancer and benign colon tumors.

中文翻译：

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血液学参数血小板对淋巴细胞的比率和血红蛋白与血小板的比率对结肠癌患者的诊断价值。

目的本研究旨在回顾性分析结肠癌患者血液学参数血小板与淋巴细胞之比（PLR）和血红蛋白与血小板之比（HPR）的价值。方法从我院电子病历中收集354例结肠癌患者，108例良性结肠肿瘤患者和123例健康对照者的血液学参数和临床资料。结果与结肠良性肿瘤组和健康对照组相比，结肠癌组的PLR值升高，HPR值降低。分析了结肠癌患者的临床病理特征与实验室参数之间的相关性，结果表明PLR和HPR均与肿瘤浸润和肿瘤大小有关。与PLR相比（AUC = 0.725，95％CI：0。682-0.765），HPR（AUC = 0.752，95％CI：0.710-0.790）或癌胚抗原（CEA）（AUC = 0.710，95％CI：0.666-0.751）单独使用，与PLR和CEA（AUC = 0.790，95％CI：0.750-0.826）或与HPR和CEA（AUC = 0.814，95％CI：0.775-0.848）可以提高区分结肠癌和良性结肠癌的特异性并产生更大的AUC。结论PLR，HPR和CEA的联合应用可提高区分结肠癌和良性结肠肿瘤的诊断效力。848）可以提高特异性，并在区分结肠癌和良性结肠癌时产生更大的AUC。结论PLR，HPR和CEA的联合应用可提高区分结肠癌和良性结肠肿瘤的诊断效力。848）可以提高特异性，并在区分结肠癌和良性结肠癌时产生更大的AUC。结论PLR，HPR和CEA的联合应用可提高区分结肠癌和良性结肠肿瘤的诊断效力。