Mesoglycan (MSG) was impregnated onto calcium alginate aerogel (CAA) to produce an innovative topical device to be applied on wounds. The main purpose of the composite material is to favor the re‐epithelialization through a direct and immediate action, also offering a protective barrier to ensure a favorable and sterilized environment for the wound healing process. Impregnation kinetics and isotherms were determined at 18 MPa and 40 and 60 °C. Composite systems were analyzed using Field Emission Scanning Electron Microscopy (FESEM), Differential Scanning Calorimetry (DSC), X-ray Diffraction (XRD), Fourier Transform Infrared (FT-IR) and UV–vis spectroscopies. A functional assay of in vitro wound healing confirmed the pro-migratory role of the composite system MSG/CAA, since an increase of the migration rate on fibroblast (BJ) cells and of the covered distance for keratinocytes (HaCaT) was observed with MSG impregnated on CAA compared to non-treated cells, CAA and pure MSG.

将中聚糖（MSG）浸渍在藻酸钙气凝胶（CAA）上，以生产一种创新的局部用器械，可用于伤口。复合材料的主要目的是通过直接和立即的作用促进再上皮形成，还提供保护性屏障，以确保为伤口愈合过程提供良好且无菌的环境。在18 MPa和40和60°C下确定浸渍动力学和等温线。使用场发射扫描电子显微镜（FESEM），差示扫描量热法（DSC），X射线衍射（XRD），傅立叶变换红外（FT-IR）和紫外可见光谱对复合系统进行了分析。体外伤口愈合的功能测定证实了复合系统MSG / CAA的促迁移作用，