Blindness and vision impairment are caused by irremediable retinal degeneration in affected individuals worldwide. Cell therapy for a retinal replacement can potentially rescue their vision, specifically for those who lost the light sensing photoreceptors in the eye. As such, well-characterized retinal cells are required for the replacement purposes. Stem cell-based therapy in photoreceptor and retinal pigment epithelium transplantation is well received, however, the drawbacks of retinal transplantation is the limited clinical protocols development, insufficient number of transplanted cells for recovery, the selection of potential stem cell sources that can be differentiated into the target cells, and the ability of cells to migrate to the host tissue. Dental pulp stem cells (DPSC) belong to a subset of mesenchymal stem cells, and are recently being studied due to its high capability of differentiating into cells of the neuronal lineage. In this review, we look into the potential uses of DPSC in treating retinal degeneration, and also the current data supporting its application.

中文翻译：

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研究牙髓干细胞在光感受器和视网膜变性疾病中的治疗。

失明和视力障碍是由全世界受影响的人无法补救的视网膜变性引起的。视网膜替代的细胞疗法可以挽救他们的视力，特别是对于那些失去了眼睛光敏感光器的人而言。这样，为了替换的目的，需要特征明确的视网膜细胞。在感光细胞和视网膜色素上皮移植中，以干细胞为基础的疗法广受欢迎，但是，视网膜移植的弊端是临床方案发展有限，移植细胞数量不足以用于恢复，选择了可以分化为干细胞的潜在干细胞。靶细胞，以及细胞迁移到宿主组织的能力。牙髓干细胞（DPSC）属于间充质干细胞的一个子集，由于其具有分化成神经元谱系细胞的高能力，因此最近正在研究中。在这篇综述中，我们研究了DPSC在治疗视网膜变性中的潜在用途，以及支持其应用的当前数据。