In this issue of Structure, Das et al. (2019) probe the structure and dynamics of dimeric cytohesins (guanine nucleotide exchange factors for ADP-ribosylation factors), in solution and on membranes. Unleashing an arsenal of methods, they demonstrate that a pleckstrin-homology domain-mediated membrane recruitment promotes conformational changes that prime cytohesins for allosteric activation.

中文翻译：

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二聚体细胞粘附素的黄金时期：一次用一只脚测量膜。


在本期《结构》中，Das 等人。 (2019) 探讨溶液中和膜上二聚体细胞粘附素（ADP-核糖基化因子的鸟嘌呤核苷酸交换因子）的结构和动力学。他们释放了一系列方法，证明普莱克斯特林同源域介导的膜募集可促进构象变化，从而为细胞粘连蛋白的变构激活做好准备。