Host genetics influence gut microbiome composition. However, determining the specific physiological mechanisms and microbes affected has been difficult due to 'cage' and 'legacy' effects in model systems. Recently, Khan et al. cleverly colonized ex-germ-free mice to demonstrate that immune genes regulate select bacterial lineages in the mouse gut.

中文翻译：

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遗传变异通过免疫改变鼠肠菌群。

宿主遗传学影响肠道微生物组的组成。但是，由于模型系统中的“笼子”和“遗留”效应，很难确定受影响的特定生理机制和微生物。最近，汗等。巧妙地定殖了无胚芽的小鼠，以证明免疫基因调节小鼠肠道中的特定细菌谱系。