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Relax, Don’t RAN Translate It
Neuron ( IF 14.7 ) Pub Date : 2019-12-04 , DOI: 10.1016/j.neuron.2019.11.014
Katherine M. Wilson , Bhavana Muralidharan , Adrian M. Isaacs

The (GGGGCC)n repeat expansion in C9orf72, which is the most common cause of frontotemporal dementia and amyotrophic lateral sclerosis, is translated through repeat-associated non-AUG (RAN) translation. In this issue of Neuron, Cheng et al. (2019) report that the helicase DDX3X, which unwinds (or relaxes) RNA, suppresses RAN translation and toxicity.



中文翻译:

放松,不要RAN翻译

的(GGGGCC)n重复扩张C9orf72,这是最常见的原因额颞叶痴呆和肌萎缩性侧索硬化,通过重复相关的非AUG(RAN)平移平移。在本期《神经元》中,Cheng等人。(2019)报告称解旋酶DDX3X可以解开(或放松)RNA,抑制RAN翻译和毒性。

更新日期:2019-12-04
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