The (GGGGCC)n repeat expansion in C9orf72, which is the most common cause of frontotemporal dementia and amyotrophic lateral sclerosis, is translated through repeat-associated non-AUG (RAN) translation. In this issue of Neuron, Cheng et al. (2019) report that the helicase DDX3X, which unwinds (or relaxes) RNA, suppresses RAN translation and toxicity.

中文翻译：

---

放松，不要RAN翻译

的（GGGGCC）n重复扩张C9orf72，这是最常见的原因额颞叶痴呆和肌萎缩性侧索硬化，通过重复相关的非AUG（RAN）平移平移。在本期《神经元》中，Cheng等人。（2019）报告称解旋酶DDX3X可以解开（或放松）RNA，抑制RAN翻译和毒性。