A Differential Circuit via Retino-Colliculo-Pulvinar Pathway Enhances Feature Selectivity in Visual Cortex through Surround Suppression.,Neuron

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A Differential Circuit via Retino-Colliculo-Pulvinar Pathway Enhances Feature Selectivity in Visual Cortex through Surround Suppression.
Neuron ( IF 14.7 ) Pub Date : 2019-12-04 , DOI: 10.1016/j.neuron.2019.10.027
Qi Fang ₁ , Xiao-Lin Chou ₁ , Bo Peng ₁ , Wen Zhong ₂ , Li I Zhang ₃ , Huizhong Whit Tao ₃

Affiliation

In the mammalian visual system, information from the retina streams into parallel bottom-up pathways. It remains unclear how these pathways interact to contribute to contextual modulation of visual cortical processing. By optogenetic inactivation and activation of mouse lateral posterior nucleus (LP) of thalamus, a homolog of pulvinar, or its projection to primary visual cortex (V1), we found that LP contributes to surround suppression of layer (L) 2/3 responses in V1 by driving L1 inhibitory neurons. This results in subtractive suppression of visual responses and an overall enhancement of orientation, direction, spatial, and size selectivity. Neurons in V1-projecting LP regions receive bottom-up input from the superior colliculus (SC) and respond preferably to non-patterned visual noise. The noise-dependent LP activity allows V1 to "cancel" noise effects and maintain its orientation selectivity under varying noise background. Thus, the retina-SC-LP-V1 pathway forms a differential circuit with the canonical retino-geniculate pathway to achieve context-dependent sharpening of visual representations.

中文翻译：

通过视网膜-胶体-脉络通路的微分电路可通过环绕声抑制增强视觉皮层中的特征选择性。

在哺乳动物的视觉系统中，来自视网膜的信息流入平行的自下而上的路径。尚不清楚这些途径如何相互作用以促进视觉皮层加工的情境调节。通过光遗传学的灭活和激活丘脑的鼠侧后核（LP），肺泡的同系物或它投射到初级视皮层（V1），我们发现LP有助于抑制周围的第（L）2/3层反应通过驱动L1抑制神经元来控制V1。这导致视觉响应的消减抑制以及方向，方向，空间和尺寸选择性的总体增强。V1投影LP区域中的神经元从上丘（SC）接收自下而上的输入，并且最好对无模式的视觉噪声做出响应。取决于噪声的LP活动允许V1达到“

更新日期：2019-12-04

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