We report oxygenated cage compounds by acetalization and ring-closing metathesis (RCM) as key steps. We used ketalization and transannular cyclization to design octacyclic triooxygenated cage compounds. In previous studies, oxepane systems have been prepared using a three-step process via Grignard addition and RCM. The present strategy described here delivers the cage bisoxepane system in two steps via ketalization process. The bisoxepane and other derivatives are confirmed by single-crystal XRD studies.

中文翻译：

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缩酮化和闭环复分解合成草笼化合物

我们报告通过缩醛化和闭环复分解（RCM）作为关键步骤的氧合笼化合物。我们使用了缩酮化和环过环化来设计八环三加氧的笼状化合物。在以前的研究中，通过格氏加成法和RCM使用三步法制备了环氧丙烷系统。这里描述的本策略通过缩酮化过程分两个步骤提供了笼型二氧杂环丁烷系统。双氧环戊烷和其他衍生物已通过单晶XRD研究确认。