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Will biomarkers be the answer for antibiotic stewardship?
The Lancet Respiratory Medicine ( IF 38.7 ) Pub Date : 2019-12-03 , DOI: 10.1016/s2213-2600(19)30406-0 Sarah B Doernberg 1
The Lancet Respiratory Medicine ( IF 38.7 ) Pub Date : 2019-12-03 , DOI: 10.1016/s2213-2600(19)30406-0 Sarah B Doernberg 1
Affiliation
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Over 50% of patients in critical care settings receive antibiotics on any given day. Because of the high incidence of resistant organisms, risk of inadequate empirical therapy in patients who are critically ill, and uncertainty of diagnosis in this setting, de-escalation of antibiotics poses a unique challenge. Therefore, clinicians tend to prescribe antibiotics expansively, even in the face of data suggesting appropriateness of narrower antibiotic courses or shorter durations. Ventilator-associated pneumonia, a common indication for antibiotics in the intensive care unit, poses a major diagnostic challenge, often leading to indiscriminate antibiotic use.
中文翻译：
生物标记物将成为抗生素管理的答案吗？
重症监护环境中超过50％的患者在任何一天都接受抗生素治疗。由于耐药菌的高发病率，危重患者经验疗法治疗的风险以及这种情况下的诊断不确定性，抗生素降级带来了独特的挑战。因此，即使面对表明更窄疗程或更短持续时间的数据，临床医生也倾向于开大药方。呼吸机相关性肺炎是重症监护病房中抗生素的常见指征，对诊断提出了重大挑战，常常导致滥用抗生素。
更新日期：2019-12-04
中文翻译：
生物标记物将成为抗生素管理的答案吗？
重症监护环境中超过50％的患者在任何一天都接受抗生素治疗。由于耐药菌的高发病率，危重患者经验疗法治疗的风险以及这种情况下的诊断不确定性，抗生素降级带来了独特的挑战。因此，即使面对表明更窄疗程或更短持续时间的数据，临床医生也倾向于开大药方。呼吸机相关性肺炎是重症监护病房中抗生素的常见指征，对诊断提出了重大挑战，常常导致滥用抗生素。
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