BACKGROUND To examine the use of ripasudil as a trabeculotomy outcome marker in patients with primary open-angle glaucoma (POAG). METHODS Between May 2015 and December 2018, 35 eyes underwent trabeculotomy and were postoperatively followed for over 3 months. Ripasudil was defined as effective if drug administration resulted in a greater than 10% reduction in intraocular pressure (IOP). Patients were divided into effective (effective group) or non-effective (non-effective group) ripasudil administration groups. The need for additional glaucoma surgery or an IOP ≥ 21 mmHg indicated surgical failure. In both groups, a Kaplan-Meier survival-analysis was used to evaluate success probabilities related to postoperative IOP levels. RESULTS Effective IOP reduction occurred in 14 of 35 eyes after ripasudil administration, which was shown by a decrease of more than 10%. Postoperatively, both groups exhibited significant reductions of IOP and antiglaucoma medication use for up to 24 months. At 12 and 24 months after trabeculotomy, probabilities of success in the effective vs. non-effective group were 100% vs. 94.7 and 100% vs. 75.4%, respectively (P = 0.14). CONCLUSIONS Trabeculotomy is effective for achieving an IOP < 21 mmHg in ripasudil effective POAG eyes. Examination of ripasudil's IOP-lowering effects may be useful in predicting surgical outcomes after trabeculotomy.

中文翻译：

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利帕舒地尔的眼内降压作用：小梁切除术的潜在结果标志。

背景技术为了研究利帕地尔在原发性开角型青光眼（POAG）患者中作为小梁切开术结局指标的用途。方法2015年5月至2018年12月，对35眼进行了小梁切除术，术后随访3个月以上。如果药物给药导致眼内压（IOP）降低大于10％，则利帕舒地被定义为有效。将患者分为有效（有效组）或无效（无效组）利帕舒地给药组。需要额外的青光眼手术或IOP≥21 mmHg表示手术失败。在两组中，均使用Kaplan-Meier生存分析来评估与术后IOP水平相关的成功概率。结果有效剂量的利福舒地尔治疗后35只眼中有14只发生了眼压降低，减少幅度超过10％。术后24个月，两组患者的眼压和抗青光眼药物用量均显着降低。小梁切开术后12个月和24个月，有效组与无效组的成功概率分别为100％vs. 94.7和100％vs. 75.4％（P = 0.14）。结论小梁切开术可有效使利帕地尔有效的POAG眼的IOP <21 mmHg。检查雷帕地尔降低眼压的作用可能有助于预测小梁切除术后的手术结果。分别为（P = 0.14）。结论小梁切开术可有效使利帕地尔有效的POAG眼的IOP <21 mmHg。检查雷帕地尔降低眼压的作用可能有助于预测小梁切除术后的手术结果。分别为（P = 0.14）。结论小梁切开术可有效使利帕地尔有效的POAG眼的IOP <21 mmHg。检查雷帕地尔降低眼压的作用可能有助于预测小梁切除术后的手术结果。