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Rhodococcus induced false-positive galactomannan (GM), a biomarker of fungal presentation, in patients with peritoneal dialysis: case reports.
BMC Nephrology ( IF 2.2 ) Pub Date : 2019-12-02 , DOI: 10.1186/s12882-019-1642-1
Tamonwan Chamroensakchai 1, 2 , Wasin Manuprasert 2 , Asada Leelahavanichkul 1 , Kullaya Takkavatakarn 3 , Nisa Thongbor 4 , Bunpring Jaroenpattrawut 5 , Talerngsak Kanjanabuch 2, 3, 6
Affiliation  

BACKGROUND Galactomannan index (GMI) at a level higher than 0.5 provides high sensitivity and specificity for the diagnosis of fungal peritonitis. Here, we report the false-positive of GMI in peritoneal dialysis (PD) effluent (PDE) due to Rhodococcus peritonitis in PD patients. CASE PRESENTATION GMI in PDE of case #1 and case #2 were 1.53 and 0.76, respectively, while serum GMI of both cases was less than 0.5. In addition, GMI from the specimens obtained directly from the stationary phase of Rhodococcus colonies were 1.27 and 1.56, which were isolated from case #1 and #2, accordingly. CONCLUSION High GMI in PDE of PD patients is not specific just for fungal infections but may also be secondary to other infections, such as Rhodococcus spp., especially in endemic areas.

中文翻译:

在腹膜透析患者中​​,红球菌诱发假阳性半乳甘露聚糖(GM),一种真菌呈递的生物标志物:病例报告。

背景技术半乳甘露聚糖指数(GMI)高于0.5,为真菌性腹膜炎的诊断提供了高灵敏度和特异性。在这里,我们报告由于PD患者的红球菌腹膜炎,腹膜透析(PD)流出物(PDE)中的GMI假阳性。病例报告#1和病例#2的PDE中的病例呈递GMI分别为1.53和0.76,而两个病例的血清GMI均小于0.5。此外,直接从红球菌属菌落固定期获得的标本中的GMI为1.27和1.56,因此分别与案例1和案例2分离。结论PD患者PDE中的高GMI不仅对真菌感染具有特异性,而且可能继发于其他感染,例如红球菌属,特别是在流行地区。
更新日期:2019-12-02
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