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Acute suppurative thyroiditis with thyroid abscess in adults: clinical presentation, treatment and outcomes.
BMC Endocrine Disorders ( IF 2.8 ) Pub Date : 2019-12-03 , DOI: 10.1186/s12902-019-0458-0
Henrik Falhammar 1, 2 , Göran Wallin 1, 3 , Jan Calissendorff 1, 2
Affiliation  

BACKGROUND Abscess in the thyroid gland is a rare but severe infectious disease. The condition can have anatomic or iatrogenic underlying causes. If untreated it could be fatal. Pathogens vary considerably. Treatment is intravenous antibiotics, drainage, and sometimes surgery. METHODS The electronic medical records of all adult patients with acute thyroiditis 2003-2017 treated at the Karolinska University Hospital (catchment area 2 million) in Sweden were systematically reviewed. RESULTS Five patients were found in the catchment area. One patient from another region but known to us was also included. Thus, six patients (aged 28-73 years) were included in the study. Median length of hospital stay was 7.5 days (4-79 days). All were treated with antibiotics (intravenous n = 5, oral n = 1). Total antibiotic treatment duration was 13.5 days (10-41 days). Blood cultures were positive in three (streptococcus pneumonia, streptococci sanguineous, pepto streptococci), deep tissue culture in three (Escherichia coli, Candida, Hemophilic influenza) and no positive culture at all in two. Drainage was used in three patients. All patients recovered without recurrences. Surgery was performed twice in the acute phase in one. There was no recurrence during 7 years (3-12) of follow-up, but one patient died after three years (severe heart failure and pneumonia). CONCLUSION Thyroid abscess in adults is extremely rare nowadays in the developed world. With prompt antibiotic therapy, drainage and in some cases thyroidectomy the prognosis seems favourable.

中文翻译:

成人急性化脓性甲状腺炎合并甲状腺脓肿:临床表现,治疗和结局。

背景技术甲状腺中的脓肿是一种罕见但严重的传染病。该疾病可能具有解剖或医源性潜在原因。如果不及时治疗可能会致命。病原体差异很大。治疗方法是静脉使用抗生素,引流,有时还需要手术。方法系统地回顾了瑞典卡罗林斯卡大学医院(集水区200万)治疗的所有2003-2017年成人急性甲状腺炎患者的电子病历。结果在集水区发现5例病人。来自另一地区但我们知道的一名患者也包括在内。因此,该研究包括了6名患者(年龄在28-73岁之间)。住院时间的中位数为7.5天(4-79天)。所有患者均接受抗生素治疗(静脉注射n = 5,口服n = 1)。抗生素的总治疗时间为13。5天(10-41天)。血液培养在三个方面呈阳性(链球菌性肺炎,血链球菌,肽链球菌),在三个组织(大肠杆菌,念珠菌,嗜血性流感)中的深层组织培养呈阳性,而在两个中则完全没有阳性培养。三名患者进行了引流。所有患者均康复,无复发。手术在急性期两次进行两次。随访7年(3-12)无复发,但3年后有1例患者死亡(严重心力衰竭和肺炎)。结论在当今发达国家,成人甲状腺脓肿已极为罕见。迅速进行抗生素治疗,引流并在某些情况下进行甲状腺切除术,预后似乎良好。在三种组织中进行深层组织培养(大肠杆菌,念珠菌,嗜血性流感),而在两种组织中完全没有阳性培养。三名患者进行了引流。所有患者均康复,无复发。手术在急性期两次进行两次。随访7年(3-12)无复发,但3年后有1例患者死亡(严重心力衰竭和肺炎)。结论在当今发达国家,成人甲状腺脓肿已极为罕见。迅速进行抗生素治疗,引流并在某些情况下进行甲状腺切除术,预后似乎良好。在三种组织中进行深层组织培养(大肠杆菌,念珠菌,嗜血性流感),而在两种组织中完全没有阳性培养。三名患者进行了引流。所有患者均康复,无复发。手术在急性期两次进行两次。随访7年(3-12)无复发,但3年后有1例患者死亡(严重心力衰竭和肺炎)。结论在当今发达国家,成人甲状腺脓肿已极为罕见。迅速进行抗生素治疗,引流并在某些情况下进行甲状腺切除术,预后似乎良好。随访7年(3-12)无复发,但3年后有1例患者死亡(严重心力衰竭和肺炎)。结论在当今发达国家,成人甲状腺脓肿已极为罕见。迅速进行抗生素治疗,引流并在某些情况下进行甲状腺切除术,预后似乎良好。随访7年(3-12)无复发,但3年后有1例患者死亡(严重心力衰竭和肺炎)。结论在当今发达国家,成年人中甲状腺脓肿已极为罕见。迅速进行抗生素治疗,引流并在某些情况下进行甲状腺切除术,预后似乎良好。
更新日期:2019-12-03
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