Although the associations between first-episode psychosis (FEP) and metabolic abnormalities on one side, and childhood trauma (CT) and risk of developing psychosis on the other are both well established, evidence on the relationship between CT and metabolic dysregulation in terms of abnormal glucose metabolism is very limited. We tested whether, already at illness onset, FEP patients with a history of CT show dysregulation of a broad range of glucose metabolism markers. In particular, in 148 FEP patients we evaluated serum concentrations of c-peptide, insulin, plasminogen-activator-inhibitor-1 (PAI-1), resistin, visfatin, glucagon, glucagon-like peptide-1 (GLP-1), gastric-inhibitor-peptide (GIP), leptin, and ghrelin. We also assessed CT with the Childhood Experience of Care and Abuse Questionnaire, and stressful life events (SLEs) with a semi-structured interview. Psychopathology, cannabis and tobacco habits, Body Mass Index (BMI) were recorded. Serum concentrations of markers were analyzed from peripheral blood. Ninety-five patients (56 % males, mean age 29.5) reported CT. Multivariate models showed that CT is associated only with the concentrations of c-peptide and insulin after adjusting for age, sex, BMI and SLEs. FEP patients who had experienced CT showed higher c-peptide and insulin serum concentrations. Our study reports that CT might be associated with the metabolic abnormalities in the first stage of psychosis, suggesting that a thorough anamnestic evaluation at psychosis onset that would include the history of CT could be helpful for clinicians in order to implement early programmes of healthy lifestyle education and to guide choice of therapeutic interventions for trauma.

中文翻译：

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首发精神病患者的童年创伤与糖代谢

尽管一方面首发精神病 (FEP) 与代谢异常之间的关联与另一方面儿童期创伤 (CT) 和发展为精神病的风险之间的关联都已确立，但就异常异常而言，CT 与代谢失调之间关系的证据葡萄糖代谢非常有限。我们测试了在疾病发作时，有 CT 病史的 FEP 患者是否表现出广泛的葡萄糖代谢标志物失调。特别是，在 148 名 FEP 患者中，我们评估了 c-肽、胰岛素、纤溶酶原-激活物-抑制剂-1 (PAI-1)、抵抗素、内脂素、胰高血糖素、胰高血糖素样肽-1 (GLP-1)、胃-抑制剂肽 (GIP)、瘦素和生长素释放肽。我们还使用童年护理和虐待经历问卷评估了 CT，和压力性生活事件 (SLE) 与半结构化访谈。记录精神病理学、大麻和烟草习惯、体重指数 (BMI)。从外周血分析标志物的血清浓度。95 名患者（56% 男性，平均年龄 29.5 岁）报告了 CT。多变量模型显示，在调整年龄、性别、BMI 和 SLE 后，CT 仅与 c 肽和胰岛素的浓度相关。经历过 CT 的 FEP 患者显示出更高的 c 肽和胰岛素血清浓度。我们的研究报告称，CT 可能与精神病第一阶段的代谢异常有关，