Celiac disease (CD) affects approximately 1% of the general population, although most cases remain unrecognized. Because CD is a multisystem disorder with protean clinical manifestations, a high index of suspicion is needed to make an appropriate diagnosis. A diagnosis of CD is made in a patient who is genetically predisposed based on the presence of compatible clinical features, positive highly specific celiac serologic findings, duodenal biopsies that document enteropathy, and improvement with a gluten-free diet. The differential diagnoses for the clinical features and the histologic findings seen in patients with CD are numerous and need to be considered; because the management of celiac disease consists of a lifelong gluten-free diet, ensuring that the diagnosis is correctly established is of utmost importance. The aim of this review is to provide practicing clinicians with the most current information on the diagnosis and management of CD, including new developments and the approach to controversial issues.

中文翻译：

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腹腔疾病。

腹腔疾病（CD）约占总人口的1％，尽管多数病例仍未被发现。由于CD是具有蛋白临床表现的多系统疾病，因此需要较高的怀疑度才能做出适当的诊断。根据具有相容性的临床特征，高度特异性的腹腔血清学阳性结果，证明肠病的十二指肠活检以及无麸质饮食的改善，对具有遗传倾向的患者进行CD诊断。CD患者的临床特征和组织学发现的鉴别诊断很多，需要加以考虑；由于腹腔疾病的治疗包括终生无麸质饮食，因此确保正确建立诊断至关重要。