Zika virus outbreaks have been explosive and unpredictable and have led to significant adverse health effects-as well as considerable public anxiety. Significant scientific work has resulted in multiple candidate vaccines that are now undergoing further clinical development, with several vaccines now in phase 2 clinical trials. In this review, we survey current vaccine efforts, preclinical and clinical results, and ethical and other concerns that directly bear on vaccine development. It is clear that the world needs safe and effective vaccines to protect against Zika virus infection. Whether such vaccines can be developed through to licensure and public availability absent significant financial investment by countries, and other barriers discussed within this article, remains uncertain.

中文翻译：

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Zika疫苗开发：现状。

寨卡病毒爆发具有爆炸性和不可预测性，已导致严重的不利健康影响以及严重的公众焦虑。重大的科学工作已导致多种候选疫苗正在接受进一步的临床开发，其中几种疫苗目前处于2期临床试验中。在这篇综述中，我们调查了当前疫苗的工作，临床前和临床结果以及与疫苗开发直接相关的道德和其他问题。显然，世界需要安全有效的疫苗来预防寨卡病毒感染。缺乏各国的大量财政投资以及本文中讨论的其他障碍，是否可以开发出此类疫苗以取得许可和公众可获得性，仍然不确定。