OBJECTIVE To determine the prevalence of major noncommunicable diseases among young adults with pediatric-onset disabilities (PoDs) compared with young adults without PoDs. PATIENTS AND METHODS Data were obtained from the Optum Clinformatics Data Mart, a de-identified nationwide claims database of beneficiaries from a single private payer in the United States. Beneficiaries were included if they were 18 to 40 years old and had an International Classification of Diseases, Ninth Revision, Clinical Modification diagnostic code for a PoD known to originate in childhood. Diagnostic codes were used to identify high-burden noncommunicable diseases: ischemic heart disease, cerebrovascular disease, hypertensive and other cardiovascular disease, type 2 diabetes, malignant cancer, osteoporosis, mood affective disorders, chronic obstructive pulmonary disease, chronic kidney disease, and liver disease. The prevalence of noncommunicable diseases and multimorbidity (≥2 diseases) was compared between adults with (N=47,077) and without (N=2,180,250) PoDs, before and after adjusting for sociodemographic characteristics. This study was conducted between July 1, 2018, and February 1, 2019. RESULTS Adults with PoDs had higher prevalences and adjusted odds of all noncommunicable diseases (odds ratio, 2.1-9.0; all P<.05) and multimorbidity (odds ratio, 3.8; 95% CI, 3.7-3.9) compared with adults without PoDs. After stratifying by the type of PoD (eg, musculoskeletal, circulatory), all PoD categories had higher prevalence of all noncommunicable diseases and multimorbidity compared with young adults without PoDs, except for ischemic heart disease and cerebrovascular disease among adults with PoDs of the genital organs. CONCLUSION Young adults with PoDs have an early onset of several noncommunicable diseases that represent major contributors to the global and national burden of disease and mortality.

中文翻译：

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早发性非传染性疾病和患有儿科发病残疾的成年人的多病症。

目的 确定与没有 PoDs 的年轻人相比，患有儿科发病残疾 (PoDs) 的年轻人主要非传染性疾病的患病率。患者和方法 数据来自 Optum Clinformatics 数据集市，这是一个去识别化的全国受益人索赔数据库，来自美国的一个私人付款人。如果受益人年龄在 18 至 40 岁之间，并且具有国际疾病分类，第九次修订，已知起源于儿童的 PoD 临床修改诊断代码，则受益人被包括在内。诊断编码用于识别高负担非传染性疾病：缺血性心脏病、脑血管病、高血压和其他心血管疾病、2型糖尿病、恶性肿瘤、骨质疏松症、情绪情感障碍、慢性阻塞性肺疾病、慢性肾病和肝病。在调整社会人口特征之前和之后，比较了有 (N=47,077) 和没有 (N=2,180,250) PoD 的成年人的非传染性疾病和合并症（≥2 种疾病）的患病率。这项研究于 2018 年 7 月 1 日至 2019 年 2 月 1 日期间进行。结果 患有 PoD 的成年人在所有非传染性疾病（优势比，2.1-9.0；所有 P<.05）和多病症（优势比， 3.8；95% CI，3.7-3.9) 与没有 PoD 的成年人相比。按 PoD 类型（例如，肌肉骨骼、循环系统）分层后，与没有 PoD 的年轻人相比，所有 PoD 类别的所有非传染性疾病和多病症的患病率都更高，除了患有生殖器官 PoD 的成年人的缺血性心脏病和脑血管疾病。结论 患有 PoD 的年轻成年人会早发多种非传染性疾病，这些疾病是全球和国家疾病负担和死亡率的主要原因。