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Sarcopenia and Type 2 diabetes mellitus as predictors of 2-year mortality after hospital discharge in a cohort of hospitalized older adults.
Diabetes Research and Clinical Practice ( IF 6.1 ) Pub Date : 2019-12-02 , DOI: 10.1016/j.diabres.2019.107969
Mileni V Beretta 1 , Fábio F Dantas Filho 1 , Raquel Eccel Freiberg 1 , Juliane V Feldman 2 , Camila Nery 2 , Ticiana C Rodrigues 1
Affiliation  

INTRODUCTION Sarcopenia has been discussed as a possible predictor of mortality in the older people, but there are few studies evaluating the relationship between mortality and sarcopenia in the population of patients with type 2 diabetes (T2D), especially after hospital discharge. OBJECTIVE To evaluate whether coexistence of sarcopenia and T2D predicts mortality after two years of hospital discharge in older patients compared to a control group without diabetes. METHODOLOGY A prospective study that included patients hospitalized between July 2015 and December 2017. To assess sarcopenia, a Timed Up and Go (TUG) test was performed, muscle strength was measured by handgrip, and muscle mass was measured across the largest calf circumference region. This project was approved by the HCPA Ethics Committee under number 150068. RESULTS 610 patients were included. The group was stratified according to the presence of diabetes, 306 (51%) patients had TD2. Patients with T2D had lower muscle strength (19.62 ± 7.53 vs. 21.19 ± 7.31p = 0.009), were slower in TUG test (23 vs. 16 s; p < 0.001) than those without T2D, 46.3% being classified as sarcopenic. The mortality rate among T2D was 28%. After adjustment, the coexistence of T2D and sarcopenia was independently associated with mortality after hospital discharge (HR: 1.78; 95% CI: 1.06-2.30). CONCLUSION Older patients with T2D and sarcopenia had a higher risk of mortality after hospital discharge compared to a control group.

中文翻译:

在一群住院的老年人中,肌肉减少症和2型糖尿病是出院后2年死亡率的预测指标。

简介讨论了减少肌肉减少症可能是老年人死亡的可能指标,但是很少有研究评估2型糖尿病(T2D)患者的死亡率和肌肉减少症之间的关系,尤其是出院后。目的评估与没有糖尿病的对照组相比,老年患者少肌症和T2D并存是否可以预测死亡率。方法学一项前瞻性研究包括2015年7月至2017年12月期间住院的患者。为评估肌肉减少症,进行了Timed Up and Go(TUG)测试,通过握力测量肌肉力量,并在最大的小腿围区域测量肌肉质量。HCPA道德委员会批准了该项目,编号为150068。结果纳入610例患者。该组根据糖尿病的存在进行分层,其中306名(51%)患者患有TD2。患有T2D的患者的肌肉强度较低(19.62±7.53 vs. 21.19±7.31p = 0.009),在TUG测试中较没有T2D的患者较慢(23 vs. 16 s; p <0.001),其中46.3%被归为肌肉减少症。T2D患者的死亡率为28%。调整后,T2D和肌肉减少症的共存与出院后的死亡率独立相关(HR:1.78; 95%CI:1.06-2.30)。结论老年T2D和肌肉减少症患者出院后的死亡率比对照组高。与没有T2D的患者相比,TUG试验的患者较慢(23 vs. 16 s; p <0.001),有46.3%被归为肌肉减少症。T2D患者的死亡率为28%。调整后,T2D和肌肉减少症的共存与出院后的死亡率独立相关(HR:1.78; 95%CI:1.06-2.30)。结论老年T2D和肌肉减少症患者出院后的死亡率比对照组高。与没有T2D的患者相比,TUG试验的患者较慢(23 vs. 16 s; p <0.001),有46.3%被归为肌肉减少症。T2D患者的死亡率为28%。调整后,T2D和肌肉减少症的共存与出院后的死亡率独立相关(HR:1.78; 95%CI:1.06-2.30)。结论老年T2D和肌肉减少症患者出院后的死亡率比对照组高。
更新日期:2019-12-02
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