Phage combination therapies for bacterial wilt disease in tomato.,Nature Biotechnology

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Phage combination therapies for bacterial wilt disease in tomato.
Nature Biotechnology ( IF 33.1 ) Pub Date : 2019-12-02 , DOI: 10.1038/s41587-019-0328-3
Xiaofang Wang ₁ , Zhong Wei ₁ , Keming Yang ₁ , Jianing Wang ₁ , Alexandre Jousset _{1,

2} , Yangchun Xu ₁ , Qirong Shen ₁ , Ville-Petri Friman _{1,

3}

Affiliation

Bacteriophages have been proposed as an alternative to pesticides to kill bacterial pathogens of crops. However, the efficacy of phage biocontrol is variable and poorly understood in natural rhizosphere microbiomes. We studied biocontrol efficacy of different phage combinations on Ralstonia solanacearum infection in tomato. Increasing the number of phages in combinations decreased the incidence of disease by up to 80% in greenhouse and field experiments during a single crop season. The decreased incidence of disease was explained by a reduction in pathogen density and the selection for phage-resistant but slow-growing pathogen strains, together with enrichment for bacterial species that were antagonistic toward R. solanacearum. Phage treatment did not affect the existing rhizosphere microbiota. Specific phage combinations have potential as precision tools to control plant pathogenic bacteria.

中文翻译：

番茄青枯病的噬菌体联合疗法。

已经提出噬菌体作为杀虫剂的替代品来杀死作物的细菌病原体。然而，在天然根际微生物组中，噬菌体生物防治的功效是多变的，并且知之甚少。我们研究了不同噬菌体组合对番茄青枯菌感染的生物防治效果。在单一作物季节的温室和田间试验中，增加组合中的噬菌体数量可将疾病发生率降低多达 80%。疾病发病率降低的原因是病原体密度的降低和对噬菌体抗性但生长缓慢的病原体菌株的选择，以及对青枯菌拮抗的细菌种类的富集。噬菌体处理不影响现有的根际微生物群。

更新日期：2019-12-02

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