当前位置：
X-MOL 学术
›
J. Exp. Med.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Modulation of the fungal mycobiome is regulated by the chitin-binding receptor FIBCD1.
Journal of Experimental Medicine ( IF 12.6 ) Pub Date : 2019-10-10 , DOI: 10.1084/jem.20182244 Jesper B Moeller 1, 2 , Irina Leonardi 3 , Anders Schlosser 2 , Anne-Laure Flamar 3 , Nicholas J Bessman 3 , Gregory Garbès Putzel 3 , Theresa Thomsen 2 , Mark Hammond 2 , Christine S Jepsen 2 , Karsten Skjødt 2 , Ernst-Martin Füchtbauer 4 , Donna L Farber 5 , Grith L Sorensen 2 , Iliyan D Iliev 3 , Uffe Holmskov 2 , David Artis 1
Journal of Experimental Medicine ( IF 12.6 ) Pub Date : 2019-10-10 , DOI: 10.1084/jem.20182244 Jesper B Moeller 1, 2 , Irina Leonardi 3 , Anders Schlosser 2 , Anne-Laure Flamar 3 , Nicholas J Bessman 3 , Gregory Garbès Putzel 3 , Theresa Thomsen 2 , Mark Hammond 2 , Christine S Jepsen 2 , Karsten Skjødt 2 , Ernst-Martin Füchtbauer 4 , Donna L Farber 5 , Grith L Sorensen 2 , Iliyan D Iliev 3 , Uffe Holmskov 2 , David Artis 1
Affiliation
|
Host-microbiota interactions are critical in regulating mammalian health and disease. In addition to bacteria, parasites, and viruses, beneficial communities of fungi (the mycobiome) are important modulators of immune- and tissue-homeostasis. Chitin is a major component of the fungal cell wall, and fibrinogen C containing domain 1 (FIBCD1) is a chitin-binding protein; however, the role of this molecule in influencing host-mycobiome interactions in vivo has never been examined. Here, we identify direct binding of FIBCD1 to intestinal-derived fungi and demonstrate that epithelial-specific expression of FIBCD1 results in significantly reduced fungal colonization and amelioration of fungal-driven intestinal inflammation. Collectively, these results identify FIBCD1 as a previously unrecognized microbial pattern recognition receptor through which intestinal epithelial cells can recognize and control fungal colonization, limit fungal dysbiosis, and dampen intestinal inflammation.
中文翻译：
几丁质结合受体FIBCD1调节真菌的真菌基因组。
宿主菌群相互作用对调节哺乳动物的健康和疾病至关重要。除细菌，寄生虫和病毒外，真菌（真菌组）的有益社区也是免疫和组织动态平衡的重要调节剂。几丁质是真菌细胞壁的主要成分，而含有纤维蛋白原C的结构域1（FIBCD1）是几丁质结合蛋白。然而，从未研究过该分子在体内影响宿主-真菌组相互作用的作用。在这里，我们确定FIBCD1与肠源性真菌的直接结合，并证明FIBCD1的上皮特异性表达导致真菌定植显着减少和真菌驱动的肠道炎症的减轻。总的来说，
更新日期：2019-12-02
中文翻译：
几丁质结合受体FIBCD1调节真菌的真菌基因组。
宿主菌群相互作用对调节哺乳动物的健康和疾病至关重要。除细菌，寄生虫和病毒外，真菌（真菌组）的有益社区也是免疫和组织动态平衡的重要调节剂。几丁质是真菌细胞壁的主要成分，而含有纤维蛋白原C的结构域1（FIBCD1）是几丁质结合蛋白。然而，从未研究过该分子在体内影响宿主-真菌组相互作用的作用。在这里，我们确定FIBCD1与肠源性真菌的直接结合，并证明FIBCD1的上皮特异性表达导致真菌定植显着减少和真菌驱动的肠道炎症的减轻。总的来说，
京公网安备 11010802027423号