Participation of white adipose tissue dysfunction on circulating HDL cholesterol and HDL particle size in apparently healthy humans,International Journal of Obesity

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Participation of white adipose tissue dysfunction on circulating HDL cholesterol and HDL particle size in apparently healthy humans
International Journal of Obesity ( IF 4.2 ) Pub Date : 2019-12-02 , DOI: 10.1038/s41366-019-0493-y
Juan G Juárez-Rojas ₁ , Ivan Torre-Villalvazo ₂ , Aida X Medina-Urrutia ₁ , Juan Reyes-Barrera ₁ , Víctor H Sainz-Escárrega ₃ , Carlos Posadas-Romero ₁ , Alejandro Macías-Cruz ₁ , Esteban Jorge-Galarza ₁

Affiliation

Objective

To use the combined presence of the elevated insulin resistance index in adipose tissue (Adipo-IR) and low values of adiponectin as a marker of dysfunctional adipose tissue, and to analyze its possible association with low values of high-density lipoprotein cholesterol (HDL-C) and small size of HDL particles.

Research design and methods

The analysis included 253 subjects with functional adipose tissue and 253 with dysfunctional adipose tissue, considering similar gender, age, and body mass index (BMI). Adipo-IR was considered when index values (free fatty acids × insulin concentrations) were ≥75th percentile. Low levels of adiponectin were considered when concentration in serum was <25th percentile (determined by ELISA). HDL size was estimated by a quantitative validated equation. Small HDL size was considered when values were <25th percentile.

Results

When comparing subjects with functional adipose tissue with those of dysfunctional adipose tissue, the latter had a higher prevalence of low HDL-C (51.4% vs. 64.0%; p = 0.004) and small HDL (56.9% vs. 67.6%; p = 0.009). Multivariate analysis indicated that independently from other metabolic risk factors, dysfunction of adipose tissue is significantly associated with low HDL-C (OR: 1.624 [CI 95%: 1.100–2.397]) and small HDL (OR: 1.462 [CI 95%: 1.000–2.139]). Adding BMI, waist circumference, and subcutaneous or visceral adipose tissue did not modify the association.

Conclusions

Dysfunction of adipose tissue is associated with a 65 and 50% higher probability of having low HDL-C and small HDL. Identification of dysfunctional adipose tissue could be a useful tool in the clinical setting to prevent the cardiometabolic risk independently from adiposity.

中文翻译：

白色脂肪组织功能障碍对表面健康人循环 HDL 胆固醇和 HDL 粒径的影响

客观的

使用脂肪组织中升高的胰岛素抵抗指数 (Adipo-IR) 和低值脂联素作为功能障碍脂肪组织的标志物，并分析其与低值高密度脂蛋白胆固醇 (HDL- C) 和小尺寸的 HDL 颗粒。

研究设计和方法

考虑到相似的性别、年龄和体重指数 (BMI)，该分析包括 253 名具有功能性脂肪组织的受试者和 253 名具有功能性脂肪组织的受试者。当指数值（游离脂肪酸 × 胰岛素浓度）≥第 75 个百分位时，考虑 Adipo-IR。当血清中的浓度<25%（由ELISA确定）时，认为脂联素水平低。HDL 大小是通过定量验证方程估计的。当值<第 25 个百分位时，考虑小 HDL 大小。

结果

当将具有功能性脂肪组织的受试者与具有功能障碍脂肪组织的受试者进行比较时，后者的低 HDL-C（51.4% 对 64.0%；p = 0.004）和小 HDL（56.9% 对 67.6%；p = 0.009）。多变量分析表明，独立于其他代谢危险因素，脂肪组织功能障碍与低 HDL-C (OR: 1.624 [CI 95%: 1.100–2.397]) 和小 HDL (OR: 1.462 [CI 95%: 1.000]) 显着相关–2.139]）。添加 BMI、腰围和皮下或内脏脂肪组织并没有改变这种关联。