Interaction of 3,4-di-tert-butyl-8-methylpyrazolo[5,1-c][1,2,4]triazine with RLi (R = n-Bu, t-Bu) at −110° ÷ −25 °C led to generation of (3,4-di-tert-butyl-8-methyl-1-R-1,4-dihydropyrazolo[5,1-c][1,2,4]triazin-4-yl)lithiums, while application of PhLi furnished a mixture of N(1)- and C(4)-addition products. Alkylation of (3,4-di-tert-butyl-8-methyl-1-R-1,4-dihydropyrazolo[5,1-c][1,2,4]triazin-4-yl)lithiums with MeI proceeded at the N(2) atom, but O₂ and H₃O⁺ selectively attacked the C(4) ring position. The protonation product could also be synthesized independently from (trans-)3-tert-butyl-8-methyl-3,4-dihydropyrazolo[5,1-c][1,2,4]triazine-3,4-diyl bispivalate and t-BuLi. 3,4-Di-tert-butyl-4-hydroperoxy-8-methyl-1-R-1,4-dihydropyrazolo[5,1-c][1,2,4]triazines underwent Criegee fragmentation at r.t. (for R = t-Bu) or transformed into C(4)-hydroxy derivative (for R = Ph). Structures of four of the isolated reaction products were established by single-crystal X-ray diffraction analyses.

3,4-二叔丁基-8-甲基吡唑并[5,1- c ] [1,2,4]三嗪与RLi（R =  n -Bu，t -Bu）在-110°÷-25相互作用°C导致生成（3,4-二叔丁基-8-甲基-1-R-1,4-二氢吡唑并[5,1- c ] [1,2,4]三嗪-4-基锂，而应用PhLi可提供N（1）-和C（4）加成产物的混合物。（3,4-二叔丁基-8-甲基-1-R-1,4-二氢吡唑并[5,1- c ] [1,2,4]三嗪-4-基）锂与MeI的烷基化反应在N（2）原子上，但O ₂和H ₃ O ⁺有选择地攻击C（4）环位置。质子化产物也可以独立于（反式）3-叔丁基-8-甲基-3,4-二氢吡唑并[5,1- c ] [1,2,4]三嗪-3,4-二基双新戊酸酯合成。和t -BuLi。3,4-二叔丁基-4-氢过氧-8-甲基-1-R-1,4-二氢吡唑并[5,1- c ] [1,2,4]三嗪在rt发生Criegee断裂（对于R =  t -Bu）或转化为C（4）-羟基衍生物（对于R = Ph）。通过单晶X射线衍射分析确定了四种分离的反应产物的结构。