Highlights • The severity of childhood trauma experience contributes to lack of response to antidepressant treatment.• Untreated depressed patients show increased diurnal cortisol levels compared with those on antidepressant medication both treatment responder and non-responder patients.• The severity of childhood trauma contributes to increased HPA axis activity and higher cortisol production specifically in depressed patients who present glucocorticoid resistance.• Glucocorticoid resistance may be a novel target for development of personalised treatment for a subgroup of depressed patients with a history of childhood trauma.

中文翻译：

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抑郁症患者的童年创伤、HPA 轴活动和抗抑郁反应

亮点 • 儿童创伤经历的严重性导致对抗抑郁治疗缺乏反应。• 与抗抑郁药物治疗有反应和无反应的患者相比，未经治疗的抑郁患者显示出昼夜皮质醇水平升高。• 儿童创伤的严重程度有助于增加HPA 轴活性和较高的皮质醇产量尤其适用于出现糖皮质激素抵抗的抑郁症患者。• 糖皮质激素抵抗可能是开发针对有儿童创伤史的抑郁症患者亚组的个性化治疗的新目标。