Impaired single breath carbon monoxide diffusing capacity (DLCO) is associated with emphysema. Small airways disease (SAD) may be a precursor lesion to emphysema, but the relationship between SAD and DLCO is undescribed. We hypothesized that in mild COPD, functional SAD (fSAD) defined by computed tomography (CT) and Parametric Response Mapping methodology would correlate with impaired DLCO. Using data from ever-smokers in the COPDGene cohort, we established that fSAD correlated significantly with lower DLCO among both non-obstructed and GOLD 1-2 subjects. The relationship between DLCO with CT-defined emphysema was present in all GOLD stages, but most prominent in severe disease. TRIAL REGISTRATION: NCT00608764. Registry: COPDGene. Registered 06 February 2008, retrospectively registered.

中文翻译：

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COPDGene中扩散能力与小气道异常之间的关系。

一口气一氧化碳扩散能力（DLCO）受损与肺气肿有关。小气道疾病（SAD）可能是肺气肿的前兆病变，但SAD和DLCO之间的关系尚未描述。我们假设在轻度COPD中，通过计算机断层扫描（CT）和参数响应映射方法定义的功能性SAD（fSAD）与DLCO受损有关。使用来自COPDGene队列中经常吸烟者的数据，我们确定在非阻塞和GOLD 1-2受试者中，fSAD与较低的DLCO显着相关。DLCO与CT定义的肺气肿之间的关系在所有GOLD阶段均存在，但在严重疾病中最为突出。试用注册：NCT00608764。注册表：COPDGene。2008年2月6日注册，追溯注册。