BACKGROUND Cuphea ignea is one of the herbal resources belonging to Lythraceae family. Some species of this family have been used traditionally in South and Central America's folk medicine for treating stomach disorders. Therefore, the present study was performed to evaluate the gastropreventive effect of aqueous ethanolic extract of C. ignea aerial parts on ethanol-induced gastric ulcer. METHODS Gastric ulcers were induced in Sprague Dawley rats using one oral dose of absolute ethanol (1.5 mL/rat). The C. ignea aerial parts extract at doses of 250 and 500 mg/kg body weight and ranitidine (a reference drug) at a dose of 30 mg/kg body weight were orally administrated daily for 7 days before ulcer induction. One hour after ethanol administration blood samples were collected and then stomachs of sacrificed rats were subjected to biochemical, macroscopic and microscopic studies. RESULTS Oral administration of C. ignea extract significantly attenuated gastric ulcer as revealed by significant reduction in the gastric ulcer index and volume of gastric juice while significantly increased preventive percentage, gastric pH value and pepsin activity. Pre-treatment of C. ignea extract markedly improved the serum level of TNF-α, the gastric MPO activity and NO content. Furthermore, C. ignea pre-treatment significantly increased the gastric levels of enzymatic and non- enzymatic antioxidants namely CAT, SOD, GSH-Px, and GSH with concomitant reduction in MDA level compared with those in the ethanol group. These results were further supported by histopathological findings which revealed the curing effect of C. ignea on the hemorrhagic shock induced by ethanol toxicity. CONCLUSIONS C. ignea extract showed a potential gastroprotective effect on ethanol-induced gastric ulcer, and its effect may be mediated through suppression of oxidative stress and gastric inflammation.

中文翻译：

---

紫花提取物对大鼠乙醇诱发的胃溃疡的抗溃疡作用。

背景技术紫铜花是属于千屈菜科的草药资源之一。该家族的某些物种传统上已在南美和中美洲的民间医学中用于治疗胃部疾病。因此，进行了本研究以评价豚鼠梭状芽孢杆菌地上部分的含水乙醇提取物对乙醇诱导的胃溃疡的胃预防作用。方法使用口服无水乙醇（1.5 mL /大鼠）在Sprague Dawley大鼠中诱发胃溃疡。在诱发溃疡之前，每天口服给予250和500mg / kg体重的烟曲霉地上部分提取物和30mg / kg体重的雷尼替丁（参考药物）。服用乙醇一小时后，收集血液样本，然后对处死的大鼠的胃进行生化分析，宏观和微观研究。结果口服C.ignea提取物可显着减轻胃溃疡，如胃溃疡指数和胃液量显着减少所揭示，而预防百分率，胃pH值和胃蛋白酶活性显着增加。烟酒假单胞菌提取物的预处理显着改善了血清TNF-α水平，胃MPO活性和NO含量。此外，烟曲霉的预处理显着提高了胃内酶促和非酶促抗氧化剂的水平，即CAT，SOD，GSH-Px和GSH，与乙醇组相比，MDA水平随之降低。这些结果进一步得到组织病理学结果的支持，该发现揭示了烟酒假单胞菌对乙醇毒性诱发的失血性休克的治愈作用。结论C．