P-selectin is an adhesion molecule translocated to the surface of endothelial cells and platelets under inflammatory stimuli, and its potential as a biomarker in inflammatory conditions has driven preclinical studies to investigate its application for molecular imaging of inflammation. Clinical imaging of P-selectin expression for disease characterization could have an important role in stratifying patients and determining treatment strategies. The objective of this review is to outline the role of P-selectin in cardiovascular inflammatory conditions and its translation as an early inflammatory biomarker for several molecular imaging modalities for diagnostic purposes and therapeutic planning.

P-选择蛋白是在炎症刺激下易位至内皮细胞和血小板表面的粘附分子，其在炎症条件下作为生物标志物的潜力推动了临床前研究，以研究其在炎症分子成像中的应用。P-选择素表达的临床影像学用于疾病表征可能在对患者进行分层和确定治疗策略中起重要作用。这篇综述的目的是概述P-选择蛋白在心血管炎性疾病中的作用，以及将其翻译为多种用于诊断目的和治疗计划的分子成像方式的早期炎性生物标记。