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Behavioural responses to a photovoltaic subretinal prosthesis implanted in non-human primates.
Nature Biomedical Engineering ( IF 26.8 ) Pub Date : 2019-12-02 , DOI: 10.1038/s41551-019-0484-2 Paul-Henri Prévot 1 , Kevin Gehere 1 , Fabrice Arcizet 1 , Himanshu Akolkar 1 , Mina A Khoei 1 , Kévin Blaize 1 , Omar Oubari 1 , Pierre Daye 1 , Marion Lanoë 1 , Manon Valet 1 , Sami Dalouz 1 , Paul Langlois 1 , Elric Esposito 1 , Valérie Forster 1 , Elisabeth Dubus 1 , Nicolas Wattiez 2 , Elena Brazhnikova 1 , Céline Nouvel-Jaillard 1 , Yannick LeMer 3 , Joanna Demilly 4 , Claire-Maëlle Fovet 4 , Philippe Hantraye 4 , Morgane Weissenburger 2 , Henri Lorach 5 , Elodie Bouillet 6 , Martin Deterre 6 , Ralf Hornig 6 , Guillaume Buc 6 , José-Alain Sahel 1, 3, 7, 8 , Guillaume Chenegros 1 , Pierre Pouget 2 , Ryad Benosman 1, 7 , Serge Picaud 1
Nature Biomedical Engineering ( IF 26.8 ) Pub Date : 2019-12-02 , DOI: 10.1038/s41551-019-0484-2 Paul-Henri Prévot 1 , Kevin Gehere 1 , Fabrice Arcizet 1 , Himanshu Akolkar 1 , Mina A Khoei 1 , Kévin Blaize 1 , Omar Oubari 1 , Pierre Daye 1 , Marion Lanoë 1 , Manon Valet 1 , Sami Dalouz 1 , Paul Langlois 1 , Elric Esposito 1 , Valérie Forster 1 , Elisabeth Dubus 1 , Nicolas Wattiez 2 , Elena Brazhnikova 1 , Céline Nouvel-Jaillard 1 , Yannick LeMer 3 , Joanna Demilly 4 , Claire-Maëlle Fovet 4 , Philippe Hantraye 4 , Morgane Weissenburger 2 , Henri Lorach 5 , Elodie Bouillet 6 , Martin Deterre 6 , Ralf Hornig 6 , Guillaume Buc 6 , José-Alain Sahel 1, 3, 7, 8 , Guillaume Chenegros 1 , Pierre Pouget 2 , Ryad Benosman 1, 7 , Serge Picaud 1
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Retinal dystrophies and age-related macular degeneration related to photoreceptor degeneration can cause blindness. In blind patients, although the electrical activation of the residual retinal circuit can provide useful artificial visual perception, the resolutions of current retinal prostheses have been limited either by large electrodes or small numbers of pixels. Here we report the evaluation, in three awake non-human primates, of a previously reported near-infrared-light-sensitive photovoltaic subretinal prosthesis. We show that multipixel stimulation of the prosthesis within radiation safety limits enabled eye tracking in the animals, that they responded to stimulations directed at the implant with repeated saccades and that the implant-induced responses were present two years after device implantation. Our findings pave the way for the clinical evaluation of the prosthesis in patients affected by dry atrophic age-related macular degeneration.
中文翻译：
对植入非人类灵长类动物的光伏视网膜下假体的行为反应。
与光感受器变性有关的视网膜营养不良和与年龄有关的黄斑变性可引起失明。在盲人患者中，尽管残余视网膜电路的电激活可以提供有用的人工视觉感知，但是当前视网膜假体的分辨率受到大电极或少量像素的限制。在这里，我们报告了在三个清醒的非人类灵长类动物中对先前报道的近红外光敏感的光伏视网膜下假体的评估。我们表明，在辐射安全范围内对假体进行多像素刺激可以使动物追踪眼睛，它们对植入物的刺激具有重复的扫视，并且植入物诱导的反应在装置植入后的两年内出现。
更新日期：2019-12-02
中文翻译：
对植入非人类灵长类动物的光伏视网膜下假体的行为反应。
与光感受器变性有关的视网膜营养不良和与年龄有关的黄斑变性可引起失明。在盲人患者中，尽管残余视网膜电路的电激活可以提供有用的人工视觉感知，但是当前视网膜假体的分辨率受到大电极或少量像素的限制。在这里，我们报告了在三个清醒的非人类灵长类动物中对先前报道的近红外光敏感的光伏视网膜下假体的评估。我们表明，在辐射安全范围内对假体进行多像素刺激可以使动物追踪眼睛，它们对植入物的刺激具有重复的扫视，并且植入物诱导的反应在装置植入后的两年内出现。
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