Evidence accumulation during a sensorimotor decision task revealed by whole-brain imaging.,Nature Neuroscience

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Evidence accumulation during a sensorimotor decision task revealed by whole-brain imaging.
Nature Neuroscience ( IF 21.2 ) Pub Date : 2019-12-02 , DOI: 10.1038/s41593-019-0535-8
Elena I Dragomir _{1,

2} , Vilim Štih _{1,

2} , Ruben Portugues ₁

Affiliation

Although animals can accumulate sensory evidence over considerable time scales to appropriately select behavior, little is known about how the vertebrate brain as a whole accomplishes this. In this study, we developed a new sensorimotor decision-making assay in larval zebrafish based on whole-field visual motion. Fish responded by swimming in the direction of perceived motion, such that the latency to initiate swimming and the fraction of correct turns were modulated by motion strength. Using whole-brain functional imaging, we identified neural activity relevant to different stages of the decision-making process, including the momentary evaluation and accumulation of sensory evidence. This activity is distributed in functional clusters across different brain regions and is characterized by a wide range of time constants. In addition, we found that the caudal interpeduncular nucleus (IPN), a circular structure located ventrally on the midline of the brain, reliably encodes the left and right turning rates.

中文翻译：

全脑成像显示在感觉运动决策任务期间的证据积累。

虽然动物可以在相当大的时间尺度适当选择行为积累的感官证据，很少有人知道如何脊椎动物大脑作为一个整体来完成这一点。在这项研究中，我们开发了一种基于全视野视觉运动的幼体斑马鱼新的感觉运动决策方法。鱼通过在感知的运动方向上游泳来做出响应，从而通过运动强度来调节开始游泳的潜伏时间和正确转弯的比例。使用全脑功能成像，我们确定了与决策过程的不同阶段相关的神经活动，包括瞬时评估和感觉证据的积累。这种活动分布在不同大脑区域的功能簇中，其特征是具有广泛的时间常数。此外，

更新日期：2019-12-02

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