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The influence of environment and origin on brain resident macrophages and implications for therapy.
Nature Neuroscience ( IF 21.2 ) Pub Date : 2019-12-02 , DOI: 10.1038/s41593-019-0545-6
Mariko L Bennett 1 , F Chris Bennett 2
Affiliation  

Microglia are the tissue-resident macrophages of the brain and spinal cord. They are critical players in the development, normal function, and decline of the CNS. Unlike traditional monocyte-derived macrophages, microglia originate from primitive hematopoiesis in the embryonic yolk sac and self-renew throughout life. Microglia also have a unique genetic signature among tissue resident macrophages. Recent studies identify the contributions of both brain environment and developmental history to the transcriptomic identity of microglia. Here we review this emerging literature and discuss the potential implications of origin on microglial function, with particular focus on existing and future therapies using bone-marrow- or stem-cell-derived cells for the treatment of neurological diseases.

中文翻译:

环境和起源对驻留于大脑的巨噬细胞的影响及其对治疗的影响。

小胶质细胞是大脑和脊髓的组织内巨噬细胞。它们是中枢神经系统发育,正常功能和衰落的关键因素。与传统的单核细胞衍生的巨噬细胞不同,小胶质细胞起源于胚胎卵黄囊的原始造血作用,并在整个生命过程中自我更新。小胶质细胞在组织常驻巨噬细胞中也具有独特的遗传特征。最近的研究确定了大脑环境和发展史对小胶质细胞转录组身份的贡献。在这里,我们回顾这些新兴文献,并讨论起源对小胶质细胞功能的潜在影响,特别关注使用骨髓或干细胞衍生细胞治疗神经系统疾病的现有和未来疗法。
更新日期:2019-12-02
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