Cortico-limbic circuits provide a substrate for adaptive behavioral and emotional responses. However, dysfunction of these circuits can result in maladaptive responses that are associated with psychopathology. The prefrontal-limbic pathways are of particular interest because they facilitate interactions among emotion, cognition, and decision-making functions, all of which are affected in psychiatric disorders. Regulatory aspects of the prefrontal cortex (PFC) are especially relevant to human psychopathology, as the PFC, in addition to its functions, is more recent from an evolutionary perspective and is considerably more complex in human and nonhuman primates compared with other species. This review provides a neuroanatomical and functional perspective of selected regions of the limbic system, the medial temporal lobe structures-the hippocampus and amygdala as well as regions of the PFC. Beyond the specific brain regions, emphasis is placed on the structure and function of critical PFC-limbic circuits, linking alterations in the processing of information across these pathways to the pathophysiology and psychopathology of various psychiatric illnesses.

中文翻译：

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皮质-肢体相互作用介导与心理病理学相关的适应性和适应性反应。

皮质-边缘电路为适应性的行为和情绪反应提供了基础。但是，这些电路的功能障碍会导致与心理病理相关的适应不良反应。额叶前缘的途径特别令人感兴趣，因为它们促进了情绪，认知和决策功能之间的相互作用，所有这些都在精神疾病中受到影响。前额叶皮层（PFC）的调控方面与人类精神病理学特别相关，因为PFC除了其功能之外，从进化的角度看也是较新的，并且与其他物种相比，在人类和非人类灵长类动物中的作用要复杂得多。这篇综述提供了边缘系统某些区域的神经解剖学和功能性观点，颞叶内侧结构-海马和杏仁核以及PFC区域。除了特定的大脑区域之外，重点还放在关键的PFC-limbic回路的结构和功能上，这些通路将信息处理过程中的变化与各种精神疾病的病理生理学和心理病理学联系起来。