New insights of CYP1A in endogenous metabolism: a focus on single nucleotide polymorphisms and diseases.,Acta Pharmaceutica Sinica B

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New insights of CYP1A in endogenous metabolism: a focus on single nucleotide polymorphisms and diseases.
Acta Pharmaceutica Sinica B ( IF 14.7 ) Pub Date : 2019-12-02 , DOI: 10.1016/j.apsb.2019.11.016
Jian Lu _{1,

2} , Xuyang Shang _{1,

2} , Weiguo Zhong ₁ , Yuan Xu ₂ , Rong Shi ₃ , Xin Wang _{1,

2}

Affiliation

Cytochrome P450 1A (CYP1A), one of the major CYP subfamily in humans, not only metabolizes xenobiotics including clinical drugs and pollutants in the environment, but also mediates the biotransformation of important endogenous substances. In particular, some single nucleotide polymorphisms (SNPs) for CYP1A genes may affect the metabolic ability of endogenous substances, leading to some physiological or pathological changes in humans. This review first summarizes the metabolism of endogenous substances by CYP1A, and then introduces the research progress of CYP1A SNPs, especially the research related to human diseases. Finally, the relationship between SNPs and diseases is discussed. In addition, potential animal models for CYP1A gene editing are summarized. In conclusion, CYP1A plays an important role in maintaining the health in the body.

中文翻译：

CYP1A在内源代谢中的新见解：关注单核苷酸多态性和疾病。

细胞色素P450 1A（CYP1A）是人类主要的CYP亚家族之一，不仅代谢包括临床药物和环境污染物在内的外源物质，还介导重要内源物质的生物转化。特别是CYP1A基因的一些单核苷酸多态性（SNP）可能会影响内源性物质的代谢能力，导致人体的一些生理或病理变化。本文首先对CYP1A对内源性物质的代谢进行综述，然后介绍CYP1A SNPs的研究进展，特别是与人类疾病相关的研究进展。最后讨论了SNP与疾病之间的关系。此外，还总结了 CYP1A 基因编辑的潜在动物模型。总之，CYP1A在维持身体健康方面发挥着重要作用。

更新日期：2019-12-02

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