A versatile biomaterial ink platform for the melt electrowriting of chemically-crosslinked hydrogels,Materials Horizons

当前位置： X-MOL 学术 › Mater. Horiz. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

A versatile biomaterial ink platform for the melt electrowriting of chemically-crosslinked hydrogels
Materials Horizons ( IF 12.2 ) Pub Date : 2019/12/02 , DOI: 10.1039/c9mh01654f
Daniel Nahm _{1,

2,

3,

4,

5} , Franziska Weigl _{4,

5,

6,

7} , Natascha Schaefer _{4,

5,

8,

9} , Ana Sancho _{4,

5,

6,

7} , Andreas Frank _{5,

10,

11,

12} , Jürgen Groll _{4,

5,

6,

7} , Carmen Villmann _{4,

5,

8,

9} , Hans-Werner Schmidt _{5,

10,

11,

12} , Paul D. Dalton _{4,

5,

6,

7} , Robert Luxenhofer _{1,

2,

3,

4,

5}

Affiliation

In this study, we designed a novel biomaterial ink platform based on hydrophilic poly(2-ethyl-2-oxazine) (PEtOzi) specifically for melt electrowriting (MEW). This material crosslinks spontaneously after processing via dynamic Diels–Alder click chemistry. These direct-written microperiodic structures rapidly swell in water to yield thermoreversible hydrogels. These hydrogels are robust enough for repeated aspiration and ejection through a cannula without structural damage, despite their high water content of 84%. Moreover, the scaffolds retain functional groups for modification using click chemistry and therefore can be readily functionalized as demonstrated using fluorophores and peptides to facilitate visualization and cell attachment. The PEtOzi hydrogel developed here is compatible with confocal imaging and staining protocols for cells. In summary, an advanced material platform based on PEtOzi is reported that is compatible with MEW and results in functionalizable chemically crosslinked microperiodic hydrogels.

中文翻译：

多功能的生物材料墨水平台，用于化学交联的水凝胶的熔体电书写

在这项研究中，我们设计了一种基于亲水性聚（2-乙基-2-恶嗪）（PEtOzi）的新型生物材料墨水平台，专门用于熔融电子书写（MEW）。这种材料处理后自发交联通过动态Diels–Alder单击化学。这些直接写的微周期结构在水中迅速溶胀，产生热可逆的水凝胶。这些水凝胶尽管具有84％的高水分含量，但仍然足以通过导管反复抽吸和排出而不会造成结构损坏。此外，支架保留了使用点击化学进行修饰的官能团，因此可以如使用荧光团和肽所证明的那样容易地官能化以促进可视化和细胞附着。此处开发的PEtOzi水凝胶与共聚焦成像和细胞染色方案兼容。总之，据报道，一种基于PEtOzi的先进材料平台与MEW兼容，可产生可官能化的化学交联的微周期水凝胶。

更新日期：2020-03-09

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11