The naturally occurring polysaccharide, β-1,3-glucans, a well-known immunostimulant, has been highly valued for many years for their health-promoting and anti-aging properties, but its mode of action is poorly understood. In this study, we first showed that oral administration of β-1,3-glucans did not affect the general condition and physiology of male mice throughout the trial period. We then showed that dietary intake of β-1,3-glucans induced a significant increase in T helper cells (CD4+) in young, middle-aged and aged male mice. We also showed that β-1,3-glucans supplementation considerably increased the delayed-type hypersensitivity (DTH) response, a T cell-mediated immune response, in young and aged mice. In addition, we found that β-1,3-glucans supplementation remarkably promoted the production of total anti-keyhole limpet hemocyanin (KLH) immunoglobulin G (IgG), anti-KLH IgG1, and anti-KLH IgG2a in young and aged mice without disturbing immune homeostasis. These data together indicate that oral administration of β-1,3-glucans enhanced the adaptive immune responses of aged mice without disturbing their general condition and physiology, supporting the idea that β-1,3-glucans are capable of counteracting the immunosenescence in mice. They also suggest that β-1,3-glucans can be clinically useful to help the elderly generate an improved response to vaccine with stronger humoral and cell-mediated immune responses.

中文翻译：

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饮食中摄入β-葡聚糖可增强衰老小鼠的适应性免疫反应，并特别强调其抗衰老活性。

天然多糖β-1,3-葡聚糖，一种众所周知的免疫刺激剂，具有促进健康和抗衰老的特性，多年来一直受到高度重视，但对其作用方式知之甚少。在这项研究中，我们首先表明口服β-1,3-葡聚糖不会在整个试验期内影响雄性小鼠的一般状况和生理。然后我们表明，饮食中β-1,3-葡聚糖的摄入可导致年轻，中年和老年雄性小鼠的T辅助细胞（CD4 +）显着增加。我们还显示，在年轻和老年小鼠中，补充β-1,3-葡聚糖可显着增加延迟型超敏反应（DTH），T细胞介导的免疫反应。另外，我们发现β-1 3-葡聚糖的补充显着促进了幼鼠和老年小鼠中总抗钥孔血蓝蛋白（KLH）免疫球蛋白G（IgG），抗KLH IgG1和抗KLH IgG2a的产生，而没有干扰免疫稳态。这些数据共同表明，口服β-1,3-葡聚糖可增强衰老小鼠的适应性免疫反应，而不会干扰它们的一般状况和生理机能，从而支持了β-1,3-葡聚糖能够抵消小鼠免疫衰老的观点。 。他们还建议，β-1,3-葡聚糖可在临床上帮助老年人改善对疫苗的反应，使其具有更强的体液和细胞介导的免疫反应。这些数据共同表明，口服β-1,3-葡聚糖可增强衰老小鼠的适应性免疫反应，而不会干扰它们的一般状况和生理机能，从而支持了β-1,3-葡聚糖能够抵消小鼠免疫衰老的观点。 。他们还建议，β-1,3-葡聚糖可在临床上帮助老年人改善对疫苗的反应，使其具有更强的体液和细胞介导的免疫反应。这些数据共同表明，口服β-1,3-葡聚糖可增强衰老小鼠的适应性免疫反应，而不会干扰它们的一般状况和生理机能，从而支持了β-1,3-葡聚糖能够抵消小鼠免疫衰老的观点。 。他们还建议，β-1,3-葡聚糖可在临床上帮助老年人改善对疫苗的反应，使其具有更强的体液和细胞介导的免疫反应。