Qixianqingming granules (QXQM) comprise a traditional Chinese medicine (TCM) formula that was developed based on the combination of TCM theory and clinical practice. This formula has been proven to effectively treat asthma. In this study, an analytical procedure using ultraperformance liquid chromatography, coupled with electrospray ionization quadrupole time-of-flight mass spectrometry, was established for the rapid separation and sensitive identification of the chemical components in QXQM and its metabolites in serum of rats. Seventy-two compounds were systematically identified in QXQM, including flavonoids, terpenoids, anthraquinones, phenylethanoid glycosides, stilbenes, alkaloids, and organic acids. Thirteen prototype compounds and 29 metabolites were detected in the serum of rats. The results provided fundamental information for further studying the mechanisms and clinical application of QXQM.

中文翻译：

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用UPLC-ESI-Q-TOF-MS分析芪先清明颗粒及其代谢产物的化学成分。

七仙清明颗粒（QXQM）包含基于中医理论和临床实践开发的中药（TCM）配方。该配方已被证明可以有效治疗哮喘。在这项研究中，建立了一种使用超高效液相色谱结合电喷雾电离四极杆飞行时间质谱的分析程序，用于快速分离和灵敏地鉴定QXQM及其大鼠血清中代谢物的化学成分。在QXQM中系统地鉴定了72种化合物，包括黄酮类化合物，萜类化合物，蒽醌，苯基乙醛糖苷，芪，生物碱和有机酸。在大鼠血清中检测到13种原型化合物和29种代谢产物。