Transcranial Electrical Stimulation and Recording of Brain Activity using Freestanding Plant‐Based Conducting Polymer Hydrogel Composites,Advanced Materials Technologies

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Transcranial Electrical Stimulation and Recording of Brain Activity using Freestanding Plant‐Based Conducting Polymer Hydrogel Composites
Advanced Materials Technologies ( IF 6.4 ) Pub Date : 2019-12-01 , DOI: 10.1002/admt.201900652
George D. Spyropoulos ₁ , Jeremy Savarin ₁ , Eliot F. Gomez ₂ , Daniel T. Simon ₂ , Magnus Berggren ₂ , Jennifer N. Gelinas _{3,

4} , Eleni Stavrinidou ₂ , Dion Khodagholy ₁

Affiliation

Transcranial electrical stimulation is a noninvasive neurostimulation technique with a wide range of therapeutic applications. However, current electrode materials are typically not optimized for this abiotic/biotic interface which requires high charge capacity, operational stability, and conformability. Here, a plant‐based composite electrode material based on the combination of aloe vera (AV) hydrogel and a conducting polymer (CP; poly(3,4‐ethylenedioxythiophene):polystyrene sulfonate, PEDOT:PSS) is reported. This material system is fabricated into films and provides biocompatibility, conformability, and stability, while offering desirable electrical properties of the PEDOT:PSS. AVCP films are also molded onto the rough surface of the skull leading to a mechanically stable and robust interface. The in vivo efficacy of the AVCP films is verified to function as stimulating and recording electrodes by placing them on the skull of a rat and concomitantly inducing focal seizures and acquiring the evoked neural activity. AVCP films pave the way for high‐quality biological interfaces that are broadly applicable and can facilitate advances in closed‐loop responsive stimulation devices.

中文翻译：

经颅电刺激并使用独立的基于植物的导电聚合物水凝胶复合材料记录大脑活动

经颅电刺激是一种无创神经刺激技术，具有广泛的治疗应用。然而，当前的电极材料通常没有针对该非生物/生物界面进行优化，该非生物/生物界面需要高充电容量，操作稳定性和适应性。此处报道了一种基于植物的复合电极材料，该材料基于芦荟（AV）水凝胶和导电聚合物（CP;聚（3,4-乙撑二氧噻吩）：聚苯乙烯磺酸盐，PEDOT：PSS）的组合。该材料系统被制成薄膜，并提供了生物相容性，顺应性和稳定性，同时提供了PEDOT：PSS所需的电性能。AVCP薄膜还模制在颅骨的粗糙表面上，从而产生机械稳定且坚固的界面。通过将AVCP膜放在大鼠的颅骨上并伴随引起局灶性癫痫发作并获得诱发的神经活性，已证实其在体内具有刺激和记录电极的功能。AVCP薄膜为广泛应用的高质量生物界面铺平了道路，可以促进闭环响应刺激设备的发展。

更新日期：2020-03-09

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