Response of inflammatory cells to biodegradable ultra-fine grained Mg-based composites.,Micron

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Response of inflammatory cells to biodegradable ultra-fine grained Mg-based composites.
Micron ( IF 2.5 ) Pub Date : 2019-11-30 , DOI: 10.1016/j.micron.2019.102796
Mieczyslawa U Jurczyk ₁ , Jakub Żurawski ₂ , Przemyslaw K Wirstlein ₃ , Kamil Kowalski ₄ , Mieczyslaw Jurczyk ₄

Affiliation

Ultra-fine grained biodegradable Mg-based Mg1Zn1Mn0.3 Zr - HA and Mg4Y5.5Dy0.5 Zr - 45S5 Bioglass composites have shown great medical potential.

Two types of these Mg-based biomaterials subjected to different treatments were tested and as shown earlier they are biocompatible.

The aim of the study is to determine how much culture media incubated with these ultra-fine trained Mg-based composites can cause inflammatory reactions and /or periodontal cell death. The incubation of composites in the medium releases metal ions into the solution. It can be assumed that this process is permanent and also occurs in the human body.

The results have shown that the effect of proinflammatory IL-6 and TNF-

cytokines results in the strongest production of the acute phase proteins in the first day on the Mg1Zn1Mn0.3 Zr-5 wt.% HA-1 wt. % Ag HF-treated biocomposite after immersion for 2 h in 40 % HF and then the fastest decrease in these processes on the third day. In turn, the inflammatory process induced on the Mg1Zn1Mn0.3 Zr-5 wt.% HA-1 wt. % Ag biomaterial, in BAX / BCL ratio assessment, is the strongest on the third day and maintains a significantly high level on the following day, which, at the same time, confirms its persistence and development. In addition, these results confirm the successively generated necrotic processes.

Ions can induce inflammatory reactions, which in the case of the implant may take a long time, which results in the loss of the implant. Even if the material is biocompatible in rapid in-vitro tests, it can induce inflammation in the body after some time due to the release of ions.

Not every treatment improves the material's properties in terms of subsequent safety.

中文翻译：

炎症细胞对可生物降解的超细颗粒镁基复合材料的反应。

可生物降解的超细颗粒镁基Mg1Zn1Mn0.3 Zr-HA和Mg4Y5.5Dy0.5 Zr-45S5生物玻璃复合材料显示出巨大的医疗潜力。

测试了两种经过不同处理的基于Mg的生物材料，如前所述，它们具有生物相容性。

该研究的目的是确定与这些超精细训练的基于Mg的复合材料一起孵育的培养基中有多少会引起炎症反应和/或牙周细胞死亡。复合物在介质中的孵育将金属离子释放到溶液中。可以假定该过程是永久的，并且也发生在人体中。

结果表明，促炎性IL-6和TNF-α的作用

在第一天，Mg1Zn1Mn0.3 Zr-5 wt。％HA-1 wt。上的细胞因子导致急性期蛋白的产生最强。％Ag HF处理的生物复合材料在40％HF中浸泡2小时后，第三天在这些过程中下降最快。反过来，在Mg1Zn1Mn0.3 Zr-5 wt。％HA-1 wt。上诱导的炎症过程。在BAX / BCL比评估中，Ag生物材料的百分比在第三天最强，在第二天保持显着高水平，同时证实了其持久性和发展性。另外，这些结果证实了相继产生的坏死过程。

离子会引起炎症反应，在植入物的情况下可能需要很长时间，这会导致植入物的损失。即使该材料在快速的体外测试中具有生物相容性，由于离子的释放，经过一段时间后它仍会在体内诱发炎症。

并非每种处理都会在随后的安全性方面改善材料的性能。