The intrinsic limitations of conventional dosages have facilitated the emergence of novel drug delivery methodologies. Drug nanonization and encapsulation in polymeric biomaterials offers a new platform to enhance therapeutic efficiency and patient compliance. The two most basic approaches for drug size reduction are top-down, bottom-up, or a combination of these methods. This review analyzes three widely investigated techniques (viz. spray drying, high pressure homogenization, and ultrasonication) along with microfluidics for drug nanonization and encapsulation in past few years. Also, the existing challenges of aforesaid methodologies and their solution through microfluidics are highlighted. Microfluidics has brought unique opportunities towards complete control over process parameters, owing to miniaturization of fluidic environment. Overall, the emergence of microfluidic technology has created exciting possibilities in the field of controlled drug delivery and has paved a way for clinical translation of nanomedicines.

常规剂量的固有局限性促进了新型药物递送方法的出现。聚合物生物材料中的药物纳米化和封装提供了一个新的平台，可提高治疗效率和患者依从性。减小药物尺寸的两种最基本方法是自上而下，自下而上或这些方法的组合。这篇综述分析了近几年广泛研究的三种技术（即喷雾干燥，高压均质化和超声处理）以及微流控技术，用于药物纳米化和封装。而且，突出了上述方法的现有挑战及其通过微流体的解决方案。由于流体环境的小型化，微流体技术为完全控制工艺参数带来了独特的机会。全面的，