Cellular function requires coordination between different organelles and metabolic cues. Mitochondria and lysosomes are essential for cellular metabolism as major contributors of chemical energy and building blocks. It is therefore pivotal for cellular function to coordinate the metabolic roles of mitochondria and lysosomes. However, these organelles do more than metabolism, given their function as fundamental signaling platforms in the cell that regulate many key processes such as autophagy, proliferation, and cell death. Mechanisms of crosstalk between mitochondria and lysosomes are discussed, both under physiological conditions and in diseases that affect these organelles.

中文翻译：

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线粒体-溶酶体串扰：从生理学到神经退行性变。

细胞功能需要不同细胞器和代谢线索之间的协调。线粒体和溶酶体是细胞代谢所必需的，是化学能和结构单元的主要贡献者。因此，细胞功能协调线粒体和溶酶体的代谢作用至关重要。但是，这些细胞器的功能不只是新陈代谢，因为它们作为细胞中基本的信号传递平台，可以调节许多关键过程，例如自噬，增殖和细胞死亡。在生理条件和影响这些细胞器的疾病中，都探讨了线粒体与溶酶体之间的串扰机制。