Emerging intraoral biosensors.,Journal of Materials Chemistry B

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Emerging intraoral biosensors.
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2020-04-29 , DOI: 10.1039/c9tb02352f
Jianwu Wang ₁ , Jing Yu , Ting Wang , Chengcheng Li , Yan Wei , Xuliang Deng , Xiaodong Chen

Affiliation

Biomedical devices that involved continuous and real-time health-care monitoring have drawn much attention in modern medicine, of which skin electronics and implantable devices are widely investigated. Skin electronics are characterized for their non-invasive access to the physiological signals, and implantable devices are superior at the diagnosis and therapy integration. Despite the significant progress achieved, many gaps remain to be explored to provide a more comprehensive overview of human health. As the connecting point of the outer environment and human systems, the oral cavity contains many unique biomarkers that are absent in skin or inner organs, and hence, this could become a promising alternative locus for designing health-care monitoring devices. In this review, we outline the status of the oral cavity during the communication of the environment and human systems and compare the intraoral devices with skin electronics and implantable devices from the biophysical and biochemical aspects. We further summarize the established diagnosis database and technologies that could be adopted to design intraoral biosensors. Finally, the challenges and potential opportunities for intraoral biosensors are discussed. Intraoral biosensors could become an important complement for existing biomedical devices to constitute a more reliable health-care monitoring system.

中文翻译：

新兴的口腔内生物传感器。

涉及连续和实时卫生保健监控的生物医学设备在现代医学中引起了很多关注，其中皮肤电子学和植入式设备得到了广泛的研究。皮肤电子设备的特点是无创地获取生理信号，而可植入设备在诊断和治疗整合方面表现出色。尽管取得了重大进展，但仍有许多差距有待探索，以更全面地概述人类健康。作为外部环境和人体系统的连接点，口腔包含许多独特的生物标记物，而这些标记物在皮肤或内部器官中不存在，因此，这可能成为设计保健监护设备的有希望的替代场所。在这篇评论中，我们概述了环境与人类系统之间的通信过程中口腔的状况，并从生物物理和生化方面比较了口腔内设备与皮肤电子设备和可植入设备。我们进一步总结了已建立的诊断数据库和可用于设计口腔生物传感器的技术。最后，讨论了口内生物传感器的挑战和潜在机会。口内生物传感器可能成为现有生物医学设备的重要补充，以构成更可靠的医疗监控系统。我们进一步总结了已建立的诊断数据库和可用于设计口腔生物传感器的技术。最后，讨论了口内生物传感器的挑战和潜在机会。口内生物传感器可能成为现有生物医学设备的重要补充，以构成更可靠的医疗监控系统。我们进一步总结了已建立的诊断数据库和可用于设计口腔生物传感器的技术。最后，讨论了口内生物传感器的挑战和潜在机会。口内生物传感器可能成为现有生物医学设备的重要补充，以构成更可靠的医疗监控系统。

更新日期：2019-11-29

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