The clean preparation of multisubstituted pyrroles under metal- and solvent-free conditions†,Green Chemistry

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The clean preparation of multisubstituted pyrroles under metal- and solvent-free conditions†
Green Chemistry ( IF 9.3 ) Pub Date : 2019-11-29 , DOI: 10.1039/c9gc02657f
Qing-Wen Gui _{1,

2,

3,

4} , Xiaoli He _{1,

2,

3,

4} , Wenjing Wang _{1,

2,

3,

4} , Huilin Zhou _{1,

2,

3,

4} , Yumei Dong _{1,

2,

3,

4} , Nengqing Wang _{1,

2,

3,

4} , Jia-Xi Tang _{4,

5,

6,

7} , Zhong Cao _{3,

4,

8,

9} , Wei-Min He _{3,

4,

8,

9}

Affiliation

A practical and sustainable protocol for the clean preparation of various multisubstituted pyrroles through an iodine-catalyzed multicomponent reaction under metal- and solvent-free conditions was developed. In the gram-scale synthesis, the desired pyrroles can be easily isolated in high-purity through simple extraction.

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