Biomaterials as Tools to Decode Immunity.,Advanced Materials

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Biomaterials as Tools to Decode Immunity.
Advanced Materials ( IF 27.4 ) Pub Date : 2019-11-29 , DOI: 10.1002/adma.201903367
Haleigh B Eppler _{1,

2} , Christopher M Jewell _{1,

2,

3,

4,

5,

6}

Affiliation

The immune system has remarkable capabilities to combat disease with exquisite selectivity. This feature has enabled vaccines that provide protection for decades and, more recently, advances in immunotherapies that can cure some cancers. Greater control over how immune signals are presented, delivered, and processed will help drive even more powerful options that are also safe. Such advances will be underpinned by new tools that probe how immune signals are integrated by immune cells and tissues. Biomaterials are valuable resources to support this goal, offering robust, tunable properties. The growing role of biomaterials as tools to dissect immune function in fundamental and translational contexts is highlighted. These technologies can serve as tools to understand the immune system across molecular, cellular, and tissue length scales. A common theme is exploiting biomaterial features to rationally direct how specific immune cells or organs encounter a signal. This precision strategy, enabled by distinct material properties, allows isolation of immunological parameters or processes in a way that is challenging with conventional approaches. The utility of these capabilities is demonstrated through examples in vaccines for infectious disease and cancer immunotherapy, as well as settings of immune regulation that include autoimmunity and transplantation.

中文翻译：

生物材料作为解码免疫的工具。

免疫系统具有以精确的选择性对抗疾病的卓越能力。这一功能使得疫苗能够提供数十年的保护，并且最近在可以治愈某些癌症的免疫疗法方面取得了进展。更好地控制免疫信号的呈现、传递和处理方式将有助于推动更强大、更安全的选择。这些进步将得到新工具的支持，这些新工具可探测免疫细胞和组织如何整合免疫信号。生物材料是支持这一目标的宝贵资源，提供强大的、可调节的特性。生物材料作为在基础和转化环境中剖析免疫功能的工具日益重要的作用得到了强调。这些技术可以作为跨分子、细胞和组织长度尺度了解免疫系统的工具。一个共同的主题是利用生物材料特征来合理指导特定免疫细胞或器官如何遇到信号。这种通过独特的材料特性实现的精确策略，允许以对传统方法具有挑战性的方式分离免疫参数或过程。这些功能的实用性通过传染病疫苗和癌症免疫治疗以及包括自身免疫和移植在内的免疫调节设置的例子得到了证明。

更新日期：2020-04-01

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