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T cell flexibility points to a metabolic checkpoint for cancer therapy.
Nature Reviews Immunology ( IF 67.7 ) Pub Date : 2020-01-01 , DOI: 10.1038/s41577-019-0256-y Yvonne Bordon 1
Nature Reviews Immunology ( IF 67.7 ) Pub Date : 2020-01-01 , DOI: 10.1038/s41577-019-0256-y Yvonne Bordon 1
Affiliation
Activated CD8+ T cells adapt to glutamine blockade through upregulation of acetate metabolism, whereas cancer cells lack this flexibility and are highly susceptible to glutamine blockade.
中文翻译:
T细胞的灵活性指向癌症治疗的代谢检查点。
活化的CD8 + T细胞通过醋酸酯代谢的上调来适应谷氨酰胺阻断,而癌细胞缺乏这种灵活性,对谷氨酰胺阻断高度敏感。
更新日期:2019-11-30
中文翻译:
T细胞的灵活性指向癌症治疗的代谢检查点。
活化的CD8 + T细胞通过醋酸酯代谢的上调来适应谷氨酰胺阻断,而癌细胞缺乏这种灵活性,对谷氨酰胺阻断高度敏感。