Epilepsy is a circuit-level brain disorder characterized by excessive or hypersynchronous epileptic seizures involving a complex epileptogenic network. Cumulative evidence suggests that the piriform cortex (PC) is a crucial site in seizure initiation, propagation, and generalization in epilepsy. The kindling model is a classic animal model of complex partial seizures with secondarily generalized tonic seizures, which is usually used for the study of epilepsy pathogenesis and preclinical anti-epilepsy drug evaluation. Various essential functions of the PC in epilepsy were discovered in the kindling model, therefore, this review focuses on discussing the role of the PC in the kindling model. We review what pathological changes happen in the PC in the kindling model, how the PC is involved in the kindling model through different interventions, and finally we also provide perspectives on some possible research directions for future studies.

中文翻译：

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癫痫的梨状皮质：我们从点燃模型中学到了什么。

癫痫病是一种电路级脑部疾病，其特征在于涉及复杂的癫痫发生网络的过度或超同步癫痫发作。累积证据表明，梨状皮层（PC）是癫痫发作，传播和泛化的关键部位。点燃模型是复杂的部分性发作与继发性全身性强直性发作的经典动物模型，通常用于研究癫痫的发病机理和临床前抗癫痫药评估。在点燃模型中发现了PC在癫痫中的各种基本功能，因此，本综述着重讨论PC在点燃模型中的作用。我们回顾了点燃模型中PC发生了哪些病理变化，通过不同的干预措施，PC如何参与点燃模型，