Organoids are multicellular culture systems that replicate tissue architecture and function, and are increasingly used as models of viral, bacterial, and protozoan infections. Organoids have great potential to improve our current understanding of helminth interactions with their hosts and to replace or reduce the dependence on using animal models. In this review, we discuss the applicability of this technology to helminth infection research, including strategies of co-culture of helminths or their products with organoids and the challenges, advantages, and drawbacks of the use of organoids for these studies. We also explore how complementing organoid systems with other cell types and components may allow more complex models to be generated in the future to further investigate helminth-host interactions.

中文翻译：

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类器官 - 宿主-蠕虫相互作用的新模型。

类器官是复制组织结构和功能的多细胞培养系统，越来越多地用作病毒、细菌和原生动物感染的模型。类器官有很大的潜力来提高我们目前对蠕虫与其宿主相互作用的理解，并取代或减少对使用动物模型的依赖。在这篇综述中，我们讨论了这项技术在蠕虫感染研究中的适用性，包括蠕虫或其产品与类器官共培养的策略，以及在这些研究中使用类器官的挑战、优点和缺点。我们还探讨了用其他细胞类型和成分补充类器官系统如何在未来生成更复杂的模型，以进一步研究蠕虫-宿主相互作用。