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Meningioma can lead to pre-operative cognitive alterations even if localized in sensorimotor areas: A multimodal MRI-neuropsychological study in a series of 46 patients.
Neuropsychologia ( IF 2.0 ) Pub Date : 2019-11-30 , DOI: 10.1016/j.neuropsychologia.2019.107288
Ilaria Guarracino 1 , Tamara Ius 2 , Miran Skrap 2 , Barbara Tomasino 1
Affiliation  

Brain tumors are generally associated with cognitive changes. Little is known about cognition in patients with meningioma - a lesion that usually shifts and compresses the brain parenchyma with a low probability of infiltrate it. We investigated the cognitive functioning in a consecutive series of 46 patients with a meningioma in the sensorimotor area in the left (LH, N = 27) or in the right (RH, N = 19) hemisphere. All the patients underwent a pre-operative neuropsychological assessment and structural MRI. Clinical symptoms varied between LH and RH meningioma patients. Impaired performance was seen in naming (19.23% noun and 35% verb naming), short-term (18.18%) and working (14.24%) memory in the LH group, and in visuo-spatial tasks (25% neglect, 21.42% visuospatial planning) in the RH group. Both groups were impaired on a sensorimotor mental imagery task (LH, 66.66% of the LH 70% of the RH meningioma patients), while only the RH meningioma group was impaired on the visuo-spatial mental imagery task. The lesion MRI maximum overlap occurred in the postcentral and paracentral lobules. Edema was maximally localized on the left superior longitudinal fasciculus and the superior part of the right superior corona radiata. We found that only the meningioma mass, and not the edema, is a predictive variable in determining patients' performance. Patients with meningioma could present with cognitive alterations at pre-surgical evaluation even if the meningioma occurs in sensorimotor areas. In the present series, a large meningioma vs. a large edema is more relevant for cognitive performance.

中文翻译:

脑膜瘤即使位于感觉运动区域也可导致术前认知改变:一项针对46例患者的多模式MRI神经心理研究。

脑肿瘤通常与认知变化有关。关于脑膜瘤患者的认知知之甚少-脑膜瘤通常会转移并压迫脑实质,而浸润的可能性很小。我们调查了连续46例脑膜瘤患者在左半球(LH,N = 27)或右半球(RH,N = 19)的感觉运动区域中的认知功能。所有患者均接受术前神经心理学评估和结构性MRI。LH和RH脑膜瘤患者的临床症状有所不同。LH组在命名(19.23%的名词和35%的动词命名),短期(18.18%)和工作(14.24%)的记忆以及视觉空间任务(忽略25%,视觉空间的21.42%)中发现性能受损。计划)。两组均在感觉运动性心理成像任务上受损(LH,RH脑膜瘤患者的LH占66.66%,其中70%),而仅RH脑膜瘤组在视觉空间心理成像任务上受损。病变MRI最大重叠发生在中央后小叶和中央小叶。水肿最大程度位于左上纵筋膜和右上电晕放射线的上半部分。我们发现只有脑膜瘤肿块而不是水肿是决定患者表现的预测变量。脑膜瘤患者即使在感觉运动区发生脑膜瘤,在术前评估中也可能表现出认知改变。在本系列文章中,大脑膜瘤与大水肿与认知表现更为相关。LH脑膜瘤患者中有70%的LH患者中有66%),而仅RH脑膜瘤组在视觉空间心理成像任务上受到了损害。病变MRI最大重叠发生在中央后小叶和中央小叶。水肿最大程度位于左上纵筋膜和右上电晕放射线的上半部分。我们发现只有脑膜瘤肿块而不是水肿是决定患者表现的预测变量。脑膜瘤患者即使在感觉运动区发生脑膜瘤,在术前评估中也可能表现出认知改变。在本系列文章中,大脑膜瘤与大水肿与认知表现更为相关。RH脑膜瘤患者中有66%患有LH,而RH脑膜瘤患者中只有RH脑膜瘤组在视觉空间心理成像任务上受损。病变MRI最大重叠发生在中央后小叶和中央小叶。水肿最大程度位于左上纵筋膜和右上电晕放射线的上半部分。我们发现只有脑膜瘤肿块而不是水肿是决定患者表现的预测变量。脑膜瘤患者即使在感觉运动区发生脑膜瘤,在术前评估中也可能表现出认知改变。在本系列文章中,大脑膜瘤与大水肿与认知表现更为相关。病变MRI最大重叠发生在中央后小叶和中央小叶。水肿最大程度位于左上纵筋膜和右上电晕放射线的上半部分。我们发现只有脑膜瘤肿块而不是水肿是决定患者表现的预测变量。脑膜瘤患者即使在感觉运动区发生脑膜瘤,在术前评估中也可能表现出认知改变。在本系列文章中,大脑膜瘤与大水肿与认知表现更为相关。病变MRI最大重叠发生在中央后小叶和中央小叶。水肿最大程度位于左上纵筋膜和右上电晕放射线的上半部分。我们发现只有脑膜瘤肿块而不是水肿是决定患者表现的预测变量。脑膜瘤患者即使在感觉运动区发生脑膜瘤,在术前评估中也可能表现出认知改变。在本系列文章中,大脑膜瘤与大水肿与认知表现更为相关。是确定患者表现的预测变量。脑膜瘤患者即使在感觉运动区发生脑膜瘤,在术前评估中也可能表现出认知改变。在本系列文章中,大脑膜瘤与大水肿与认知表现更为相关。是确定患者表现的预测变量。脑膜瘤患者即使在感觉运动区发生脑膜瘤,在术前评估中也可能表现出认知改变。在本系列文章中,大脑膜瘤与大水肿与认知表现更为相关。
更新日期:2019-11-30
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