STUDY OBJECTIVES Sleep disorders are significant problems in patients with rheumatoid arthritis (RA) and are associated with poor quality of life. Irisin is myokine which may have anti-inflammatory and energy regulatory roles. This study assessed the association of serum irisin levels with the quality of sleep and disease activity in RA patients. METHODS In sum, 58 RA patients and 30 matched healthy controls were included. Disease activity score in 28 joints (DAS28-ESR) and the patients' global score were calculated. RA patients were grouped according to the Pittsburgh Sleep Quality Index score (PSQI) into good-sleepers (group 1) defined as a PQSI score≤5 and poor sleepers (group 2) with a PSQI > 5. Serum irisin levels were measured for both patients and controls by commercially available enzyme-linked immunosorbent assay kits. RESULTS Poor sleep quality was found in 26 (45%) of the RA patients. Irisin levels were significantly lower in RA patients with poor sleep compared to those with good sleep and healthy controls (p < 0.001). Serum irisin levels correlated inversely with disease duration, morning stiffness duration, DAS28-ESR, global score, and total PSQI score (r = -0.722 to -0.263 & p values≤0.001-0.04) indicating a possible anti-inflammatory role of irisin in RA patients. The analysis employed Student's t-test, ANOVA, and Pearson correlation. CONCLUSIONS Irisin levels were decreased in RA patients with poor sleep quality compared to RA patients with good sleep quality and healthy controls, indicating a possible association of decreased serum irisin with sleep impairment in RA patients.

中文翻译：

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类风湿关节炎患者血清虹膜素水平与睡眠质量差之间关系的初步研究。

研究目的睡眠障碍是类风湿关节炎（RA）患者的重要问题，并且与生活质量差有关。鸢尾素是肌动蛋白，可能具有抗炎和能量调节作用。这项研究评估了血清虹膜素水平与RA患者的睡眠质量和疾病活动之间的关系。方法总共包括58例RA患者和30例匹配的健康对照者。计算28个关节的疾病活动评分（DAS28-ESR）和患者的整体评分。根据匹兹堡睡眠质量指数评分（PSQI）将RA患者分为PQSI评分≤5的良好睡眠者（第1组）和PSQI> 5的不良睡眠者（第2组）。病人和对照通过市售的酶联免疫吸附测定试剂盒。结果发现有26名（45％）RA患者的睡眠质量较差。与睡眠良好和健康对照的RA患者相比，睡眠不良的RA患者的鸢尾素水平显着降低（p <0.001）。血清鸢尾素水平与疾病持续时间，晨僵持续时间，DAS28-ESR，总体评分和总PSQI评分呈负相关（r = -0.722至-0.263且p值≤0.001-0.04），表明鸢尾素可能具有抗炎作用RA患者。该分析采用了学生t检验，ANOVA和Pearson相关性。结论与具有良好睡眠质量和健康对照组的RA患者相比，睡眠质量较差的RA患者的鸢尾素水平降低，这表明RA患者的血清虹膜素降低与睡眠障碍可能相关。与睡眠良好和健康对照的RA患者相比，睡眠不良的RA患者的鸢尾素水平显着降低（p <0.001）。血清鸢尾素水平与疾病持续时间，晨僵持续时间，DAS28-ESR，总体评分和总PSQI评分呈负相关（r = -0.722至-0.263且p值≤0.001-0.04），表明鸢尾素可能具有抗炎作用RA患者。该分析采用了学生t检验，ANOVA和Pearson相关性。结论与具有良好睡眠质量和健康对照组的RA患者相比，睡眠质量较差的RA患者的鸢尾素水平降低，这表明RA患者的血清虹膜素降低与睡眠障碍可能相关。与睡眠良好和健康对照的RA患者相比，睡眠不良的RA患者的鸢尾素水平显着降低（p <0.001）。血清鸢尾素水平与疾病持续时间，晨僵持续时间，DAS28-ESR，总体评分和总PSQI评分呈负相关（r = -0.722至-0.263且p值≤0.001-0.04），表明鸢尾素可能具有抗炎作用RA患者。该分析采用了学生t检验，ANOVA和Pearson相关性。结论与具有良好睡眠质量和健康对照组的RA患者相比，睡眠质量较差的RA患者的鸢尾素水平降低，这表明RA患者的血清虹膜素降低与睡眠障碍可能相关。血清鸢尾素水平与疾病持续时间，晨僵持续时间，DAS28-ESR，总体评分和总PSQI评分呈负相关（r = -0.722至-0.263且p值≤0.001-0.04），表明鸢尾素可能具有抗炎作用RA患者。该分析采用了学生t检验，ANOVA和Pearson相关性。结论与具有良好睡眠质量和健康对照组的RA患者相比，睡眠质量较差的RA患者的鸢尾素水平降低，这表明RA患者的血清虹膜素降低与睡眠障碍可能相关。血清鸢尾素水平与疾病持续时间，晨僵持续时间，DAS28-ESR，总体评分和总PSQI评分呈负相关（r = -0.722至-0.263且p值≤0.001-0.04），表明鸢尾素可能具有抗炎作用RA患者。该分析采用了学生t检验，ANOVA和Pearson相关性。结论与具有良好睡眠质量和健康对照组的RA患者相比，睡眠质量较差的RA患者的鸢尾素水平降低，这表明RA患者的血清虹膜素降低与睡眠障碍可能相关。该分析采用了学生t检验，ANOVA和Pearson相关性。结论与具有良好睡眠质量和健康对照组的RA患者相比，睡眠质量较差的RA患者的鸢尾素水平降低，这表明RA患者的血清虹膜素降低与睡眠障碍可能相关。该分析采用了学生t检验，ANOVA和Pearson相关性。结论与具有良好睡眠质量和健康对照组的RA患者相比，睡眠质量较差的RA患者的鸢尾素水平降低，这表明RA患者的血清虹膜素降低与睡眠障碍可能相关。