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Effect of Parkinson's disease and related medications on the composition of the fecal bacterial microbiota.
npj Parkinson's Disease ( IF 6.7 ) Pub Date : 2019-11-29 , DOI: 10.1038/s41531-019-0100-x Severin Weis 1 , Andreas Schwiertz 2 , Marcus M Unger 3 , Anouck Becker 3 , Klaus Faßbender 3 , Stefan Ratering 4 , Matthias Kohl 5 , Sylvia Schnell 4 , Karl-Herbert Schäfer 6 , Markus Egert 1
npj Parkinson's Disease ( IF 6.7 ) Pub Date : 2019-11-29 , DOI: 10.1038/s41531-019-0100-x Severin Weis 1 , Andreas Schwiertz 2 , Marcus M Unger 3 , Anouck Becker 3 , Klaus Faßbender 3 , Stefan Ratering 4 , Matthias Kohl 5 , Sylvia Schnell 4 , Karl-Herbert Schäfer 6 , Markus Egert 1
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Parkinson's disease (PD) is one of the most common neurodegenerative disorders. PD patients suffer from gastrointestinal dysfunctions and alterations of the autonomous nervous system, especially its part in the gut wall, i.e., the enteric nervous system (ENS). Such alterations and functional gastrointestinal deficits often occur years before the classical clinical symptoms of PD appear. Until now, only little is known about PD-associated changes in gut microbiota composition and their potential implication in PD development. In order to increase knowledge in this field, fecal samples of 34 PD patients and 25 healthy, age-matched control persons were investigated. Here, the V4 and V5 hypervariable region of bacterial 16S rRNA genes was PCR-amplified and sequenced using an Ion Torrent PGM platform. Within the PD group, we observed a relative decrease in bacterial taxa which are linked to health-promoting, anti-inflammatory, neuroprotective or other beneficial effects on the epithelial barrier, such as Faecalibacterium and Fusicatenibacter. Both taxa were lowered in PD patients with elevated levels of the fecal inflammation marker calprotectin. In addition, we observed an increase in shares of the Clostridiales family XI and their affiliated members in these samples. Finally, we found that the relative abundances of the bacterial genera Peptoniphilus, Finegoldia, Faecalibacterium Fusicatenibacter, Anaerococcus, Bifidobacterium, Enterococcus, and Ruminococcus were significantly influenced by medication with L-dopa and entacapone, respectively. Our data confirm previously reported effects of COMT inhibitors on the fecal microbiota of PD patients and suggest a possible effect of L-dopa medication on the relative abundance of several bacterial genera.
中文翻译：
帕金森氏病和相关药物对粪便细菌菌群组成的影响。
帕金森氏病（PD）是最常见的神经退行性疾病之一。PD患者患有胃肠功能障碍和自主神经系统的改变，特别是其在肠壁中的部分，即肠神经系统（ENS）。此类改变和功能性胃肠功能衰竭通常在PD的经典临床症状出现之前数年就出现。到目前为止，关于PD相关的肠道菌群组成的变化及其对PD发展的潜在影响知之甚少。为了增加在该领域的知识，调查了34名PD患者和25名年龄匹配的健康对照者的粪便样本。在这里，细菌16S rRNA基因的V4和V5高变区经过PCR扩增，并使用Ion Torrent PGM平台进行了测序。在PD组中，我们观察到细菌类群的相对减少，这与促进健康，消炎，神经保护或对上皮屏障的其他有益作用有关，例如Faecalibacterium和Fusicatenibacter。粪便炎症标志物钙卫蛋白水平升高的PD患者的两种分类均降低。此外，在这些样本中，我们观察到了梭状芽胞杆菌家族XI及其附属成员的份额有所增加。最后，我们发现，L-多巴和entacapone的药物分别显着影响了细菌属Peptoniphilus，Finegoldia，Faecalibacterium Fusicatenibacter，Anaerococcus，Bifidobacterium，Enterococcus和Ruminococcus的相对丰度。
更新日期：2019-11-29
中文翻译：
帕金森氏病和相关药物对粪便细菌菌群组成的影响。
帕金森氏病（PD）是最常见的神经退行性疾病之一。PD患者患有胃肠功能障碍和自主神经系统的改变，特别是其在肠壁中的部分，即肠神经系统（ENS）。此类改变和功能性胃肠功能衰竭通常在PD的经典临床症状出现之前数年就出现。到目前为止，关于PD相关的肠道菌群组成的变化及其对PD发展的潜在影响知之甚少。为了增加在该领域的知识，调查了34名PD患者和25名年龄匹配的健康对照者的粪便样本。在这里，细菌16S rRNA基因的V4和V5高变区经过PCR扩增，并使用Ion Torrent PGM平台进行了测序。在PD组中，我们观察到细菌类群的相对减少，这与促进健康，消炎，神经保护或对上皮屏障的其他有益作用有关，例如Faecalibacterium和Fusicatenibacter。粪便炎症标志物钙卫蛋白水平升高的PD患者的两种分类均降低。此外，在这些样本中，我们观察到了梭状芽胞杆菌家族XI及其附属成员的份额有所增加。最后，我们发现，L-多巴和entacapone的药物分别显着影响了细菌属Peptoniphilus，Finegoldia，Faecalibacterium Fusicatenibacter，Anaerococcus，Bifidobacterium，Enterococcus和Ruminococcus的相对丰度。
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