The aging of the skin is the most visible and obvious manifestation of organismal aging and may serve as a predictor of life expectancy and health. It is, however, also the human desire for long-lasting beauty that further raises interests in the topic, and thus considerable means and efforts are put into studying the mechanisms of skin aging in basic and applied research. Both medical und non-medical interests are of benefit for skin research in general because the results from these studies help to deepen our understanding of the complex molecular, biological, cell signaling, developmental and immunological processes in this organ. In fact, the skin is an ideal organ to observe and analyze the impact of extrinsic and intrinsic drivers of aging. Within the past five years technological advances like lineage tracing of cells in model organisms, intra-vital microscopy, nucleic acid sequencing at the single cell level, and high resolution mass spectrometry have allowed to study aging and senescence of individual skin cells within the tissue context, their signaling and communication, and to derive new hypotheses for experimental studies in vitro. In this short review we will discuss very recent developments that promise to extend the existing knowledge on cell aging and senescence of dermal fibroblasts and epidermal keratinocytes in skin aging.

中文翻译：

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皮肤衰老中的细胞衰老和细胞衰老-成纤维细胞和角质形成细胞生物学的最新进展。

皮肤的衰老是机体衰老的最明显和最明显的表现，并且可以作为预期寿命和健康的预测指标。然而，人类对持久美的渴望也进一步引起了人们对该主题的兴趣，因此在基础研究和应用研究中投入了大量的手段和精力来研究皮肤衰老的机理。总体而言，医学研究和非医学研究都对皮肤研究有利，因为这些研究的结果有助于加深我们对该器官中复杂的分子，生物学，细胞信号传导，发育和免疫学过程的理解。实际上，皮肤是观察和分析外部和内在衰老驱动因素影响的理想器官。在过去的五年中，技术进步，例如模型有机体中细胞的谱系追踪，活体内显微镜检查，单细胞水平的核酸测序和高分辨率质谱分析技术可以研究组织背景内单个皮肤细胞的衰老和衰老，它们的信号传导和交流，并为体外实验研究提供新的假设。在这篇简短的评论中，我们将讨论非常新的进展，这些进展有望扩展有关皮肤衰老中皮肤成纤维细胞和表皮角质形成细胞衰老的现有知识。